Anti-Human IL6R Recombinant Antibody (Tocilizumab/Atlizumab) (CAT#: TAB-026)

Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

Host: Mouse

Isotype: IgG1 - kappa

Applications: ELISA, FC, IP, FuncS, IF, Neut, ICC


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 The inhibitory profile of tocilizumab is independent of IL-6R expression.

A , equal numbers of Ba/F3-gp130 cells were cultured for 2 days with 10 ng/ml Hyper-IL-6, 10 ng/ml human, or 10 ng/ml murine IL-6. As a control, Ba/F3-gp130 cells were cultured without any cytokine. B , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001–10,000 ␮ g/ml). C , equal numbers of Ba/F3-gp130 or Ba/F3-gp130-hIL-6R cells were cultured for 2 days with 10 ng/ml hIL-6 plus increasing concentrations of shIL-6R as indicated. D , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 plus 200 ng/ml shIL-6R and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001– 10,000 ug/ml). Statistical analysis was carried out using a paired Student's t test, and statistical significance was p< 0.01 (**). The proliferation measured with the lowest inhibitor concentration was about the same as without inhibitor.

Garbers, C. , Thaiss, W. , Jones, G. W. , Waetzig, G. H. , Lorenzen, I. , & Guilhot, F. , et al. (2011). Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor *. Journal of Biological Chemistry, 286.


Specifications

  • Immunogen
  • IL-6R bound to Sepharose4B.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • ELISA, FC, IP, FuncS, IF, Neut, ICC
  • Trade name
  • tocilizumab, tocilizumab
  • CAS
  • 375823-41-9
  • Generic Name
  • tocilizumab/Atlizumab
  • Biological Half-Life
  • 8–14 days during steady state (dependent on concentration)
  • ATC Code
  • L04AC07
  • UNII
  • I031V2H011
  • ChEMBL
  • CHEMBL1237022
  • MW
  • 145.0 kDa

Product Property

  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The IL6R antibody has been reported in applications of Inhib.

Target

  • Alternative Names
  • tocilizumab/Atlizumab;tocilizumab, rotocilizumab;375823-41-9;atlizumab;tocilizumab ;Rotocilizumab;IL6R;interleukin 6 receptor;interleukin-6 receptor subunit alpha;CD126;IL-6R 1;CD126 antigen;membrane glycoprotein 80;IL-6 receptor subunit alpha;gp80;IL6RA;IL-6RA;IL-6R-1;M

Related Resources

  • Biosimilar Overview
Please refer to Tocilizumab-Atlizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tocilizumab-Atlizumab.
Please refer to Tocilizumab-Atlizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tocilizumab-Atlizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Tocilizumab/Atlizumab"

Afuco™ Anti-IL6R ADCC Recombinant Antibody (Tocilizumab/Atlizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

See other products for "IL6R"

Recombinant Antibody

CAT Product Name Application Type
MOB-1237z Mouse Anti-IL6R Recombinant Antibody (clone 23B11) ICC, IF, IHC, FC, IP, ELISA Mouse IgG1
MOB-2310MZ Recombinant Mouse Anti-Human IL6R Antibody (clone C-O23) FC, WB Mouse antibody
HPAB-0016-YC Human Anti-IL6R Recombinant Antibody (HPAB-0016-YC) ELISA, Neut Human IgG
HPAB-0446-WJ Mouse Anti-IL6R Recombinant Antibody (HPAB-0446-WJ) ELISA Mouse IgG1
HPAB-0612-WJ Mouse Anti-IL6R Recombinant Antibody (HPAB-0612-WJ) ELISA, FC Mouse IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-L080E IL6-PE immunotoxin Cytotoxicity assay, Functional assay
AGTO-L080D IL6-DT immunotoxin Cytotoxicity assay, Functional assay

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-245 Human Anti-IL6R Recombinant Antibody (clone 6RL9); scFv Fragment WB, Neut, FuncS Human scFv
HPAB-0016-YC-S(P) Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0016-YC-S(P)) ELISA, Neut Human scFv
HPAB-0251CQ-S(P) Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0251CQ-S(P)) ELISA, FC, Block Human scFv
HPAB-0612-WJ-S(P) Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0612-WJ-S(P)) ELISA, FC Mouse scFv
HPAB-AP721-YC-S(P) Human Anti-IL6R Recombinant Antibody (clone F2); scFv Fragment ELISA, Inhib, FuncS Human scFv

Mouse Antibody

CAT Product Name Application Type
TAB-690LC Anti-human IL6R Recombinant Antibody (PM-1) (TAB-690LC) ELISA
TAB-694LC Rabbit Anti-IL6R Recombinant Antibody (TAB-694LC) ELISA Rabbit IgG
TAB-695LC Rabbit Anti-IL6R Recombinant Antibody (TAB-695LC) ELISA Rabbit IgG
TAB-690LC-F(E) Anti-human IL6R Fab Fragment (PM-1) ELISA
TAB-694LC-F(E) Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-694LC-F(E)) ELISA Rabbit Fab

Humanized Antibody

CAT Product Name Application Type
TAB-691LC-S(P) Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) ELISA Humanized scFv
TAB-692LC-S(P) Anti-human IL6R scFv Fragment (BOW070) ELISA Humanized antibody
TAB-696LC-S(P) Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) ELISA Humanized scFv
TAB-697LC-S(P) Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) ELISA Humanized scFv
TAB-032ML Anti-Human IL6R Recombinant Antibody (Satralizumab) ELISA, IHC, FC, IP, IF, FuncS IgG2, κ

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1485CQ Mouse Anti-IL6R Recombinant Antibody (clone CBL212) FC, ELISA, Neut Mouse IgG1, κ
NEUT-1486CQ Mouse Anti-IL6R Recombinant Antibody (clone CBL261) FC, Neut Mouse IgG1
NEUT-1487CQ Mouse Anti-IL6R Recombinant Antibody (clone CBL279) Neut, WB, ELISA, FC Mouse IgG1
NEUT-1489CQ Mouse Anti-IL6R Recombinant Antibody (clone CBL425) WB, FC, CyTOF, ELISA, Neut Mouse IgG1
NEUT-1491CQ Mouse Anti-IL6R Recombinant Antibody (clone MM0409-6M30) WB, Neut Mouse IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-1488CQ Mouse Anti-IL6R Recombinant Antibody (clone B-F19) Block Mouse IgG1
NEUT-1490CQ Mouse Anti-IL6R Recombinant Antibody (clone B-R6) IHC-Fr, Inhib, FC, IP Mouse IgG1

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0016-YC-F(E) Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0016-YC-F(E)) ELISA, Neut Human Fab
HPAB-0331-CN-F(E) Human Anti-IL6R Recombinant Antibody (HPAB-0331-CN-F(E)); Fab Fragment ELISA, FC, Neut Human Fab
HPAB-0332-CN-F(E) Human Anti-IL6R Recombinant Antibody (HPAB-0332-CN-F(E)); Fab Fragment ELISA, FC, Block Human Fab
HPAB-0333-CN-F(E) Human Anti-IL6R Recombinant Antibody (HPAB-0333-CN-F(E)); Fab Fragment ELISA, FC, Block Human Fab
HPAB-0718-CN-F(E) Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0718-CN-F(E)) ELISA, Neut Humanized Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-026 Afuco™ Anti-IL6R ADCC Recombinant Antibody (Tocilizumab/Atlizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-032ML Afuco™ Anti-IL6R ADCC Recombinant Antibody (Satralizumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-691LC Afuco™ Anti-IL6R ADCC Recombinant Antibody (Sapelizumab), ADCC Enhanced ELISA ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-026. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
Send Inquiry
© 2023 Creative BioLabs. All Rights Reserved
  • 0
  • 0
Cart