Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.
Host: Mouse
Isotype: IgG1 - kappa
Applications: ELISA, FC, IP, FuncS, IF, Neut, ICC
Figure 1 The inhibitory profile of tocilizumab is independent of IL-6R expression.
A , equal numbers of Ba/F3-gp130 cells were cultured for 2 days with 10 ng/ml Hyper-IL-6, 10 ng/ml human, or 10 ng/ml murine IL-6. As a control, Ba/F3-gp130 cells were cultured without any cytokine. B , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001–10,000 g/ml). C , equal numbers of Ba/F3-gp130 or Ba/F3-gp130-hIL-6R cells were cultured for 2 days with 10 ng/ml hIL-6 plus increasing concentrations of shIL-6R as indicated. D , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 plus 200 ng/ml shIL-6R and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001– 10,000 ug/ml). Statistical analysis was carried out using a paired Student's t test, and statistical significance was p< 0.01 (**). The proliferation measured with the lowest inhibitor concentration was about the same as without inhibitor.
Garbers, C. , Thaiss, W. , Jones, G. W. , Waetzig, G. H. , Lorenzen, I. , & Guilhot, F. , et al. (2011). Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor *. Journal of Biological Chemistry, 286.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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Afuco™ Anti-IL6R ADCC Recombinant Antibody (Tocilizumab/Atlizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.
CAT | Product Name | Application | Type |
MOB-1237z | Mouse Anti-IL6R Recombinant Antibody (clone 23B11) | ICC, IF, IHC, FC, IP, ELISA | Mouse IgG1 |
MOB-2310MZ | Recombinant Mouse Anti-Human IL6R Antibody (clone C-O23) | FC, WB | Mouse antibody |
HPAB-0016-YC | Human Anti-IL6R Recombinant Antibody (HPAB-0016-YC) | ELISA, Neut | Human IgG |
HPAB-0446-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0446-WJ) | ELISA | Mouse IgG1 |
HPAB-0612-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0612-WJ) | ELISA, FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
AGTO-L080E | IL6-PE immunotoxin | Cytotoxicity assay, Functional assay | |
AGTO-L080D | IL6-DT immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
PSBL-245 | Human Anti-IL6R Recombinant Antibody (clone 6RL9); scFv Fragment | WB, Neut, FuncS | Human scFv |
HPAB-0016-YC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0016-YC-S(P)) | ELISA, Neut | Human scFv |
HPAB-0251CQ-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0251CQ-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-0612-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0612-WJ-S(P)) | ELISA, FC | Mouse scFv |
HPAB-AP721-YC-S(P) | Human Anti-IL6R Recombinant Antibody (clone F2); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
CAT | Product Name | Application | Type |
TAB-690LC | Anti-human IL6R Recombinant Antibody (PM-1) (TAB-690LC) | ELISA | |
TAB-694LC | Rabbit Anti-IL6R Recombinant Antibody (TAB-694LC) | ELISA | Rabbit IgG |
TAB-695LC | Rabbit Anti-IL6R Recombinant Antibody (TAB-695LC) | ELISA | Rabbit IgG |
TAB-690LC-F(E) | Anti-human IL6R Fab Fragment (PM-1) | ELISA | |
TAB-694LC-F(E) | Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-694LC-F(E)) | ELISA | Rabbit Fab |
CAT | Product Name | Application | Type |
TAB-691LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) | ELISA | Humanized scFv |
TAB-692LC-S(P) | Anti-human IL6R scFv Fragment (BOW070) | ELISA | Humanized antibody |
TAB-696LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) | ELISA | Humanized scFv |
TAB-697LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) | ELISA | Humanized scFv |
TAB-032ML | Anti-Human IL6R Recombinant Antibody (Satralizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
CAT | Product Name | Application | Type |
NEUT-1485CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL212) | FC, ELISA, Neut | Mouse IgG1, κ |
NEUT-1486CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL261) | FC, Neut | Mouse IgG1 |
NEUT-1487CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL279) | Neut, WB, ELISA, FC | Mouse IgG1 |
NEUT-1489CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL425) | WB, FC, CyTOF, ELISA, Neut | Mouse IgG1 |
NEUT-1491CQ | Mouse Anti-IL6R Recombinant Antibody (clone MM0409-6M30) | WB, Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
NEUT-1488CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-F19) | Block | Mouse IgG1 |
NEUT-1490CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-R6) | IHC-Fr, Inhib, FC, IP | Mouse IgG1 |
CAT | Product Name | Application | Type |
HPAB-0016-YC-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0016-YC-F(E)) | ELISA, Neut | Human Fab |
HPAB-0331-CN-F(E) | Human Anti-IL6R Recombinant Antibody (HPAB-0331-CN-F(E)); Fab Fragment | ELISA, FC, Neut | Human Fab |
HPAB-0332-CN-F(E) | Human Anti-IL6R Recombinant Antibody (HPAB-0332-CN-F(E)); Fab Fragment | ELISA, FC, Block | Human Fab |
HPAB-0333-CN-F(E) | Human Anti-IL6R Recombinant Antibody (HPAB-0333-CN-F(E)); Fab Fragment | ELISA, FC, Block | Human Fab |
HPAB-0718-CN-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0718-CN-F(E)) | ELISA, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
AFC-TAB-026 | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Tocilizumab/Atlizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-032ML | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Satralizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-691LC | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Sapelizumab), ADCC Enhanced | ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.