Anti-Human IL6R Therapeutic Antibody (Tocilizumab/Atlizumab) (CAT#: TAB-026)

Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

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Figure 1 The inhibitory profile of tocilizumab is independent of IL-6R expression.

A , equal numbers of Ba/F3-gp130 cells were cultured for 2 days with 10 ng/ml Hyper-IL-6, 10 ng/ml human, or 10 ng/ml murine IL-6. As a control, Ba/F3-gp130 cells were cultured without any cytokine. B , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001–10,000 ␮ g/ml). C , equal numbers of Ba/F3-gp130 or Ba/F3-gp130-hIL-6R cells were cultured for 2 days with 10 ng/ml hIL-6 plus increasing concentrations of shIL-6R as indicated. D , equal numbers of Ba/F3-gp130, Ba/F3-gp130-hIL-6R, or Ba/F3-gp130-mIL-6R cells were cultured for 2 days with 10 ng/ml human IL-6 plus 200 ng/ml shIL-6R and increasing concentrations of the anti-human-IL-6R antibody tocilizumab (0.001– 10,000 ug/ml). Statistical analysis was carried out using a paired Student's t test, and statistical significance was p< 0.01 (**). The proliferation measured with the lowest inhibitor concentration was about the same as without inhibitor.

Garbers, C. , Thaiss, W. , Jones, G. W. , Waetzig, G. H. , Lorenzen, I. , & Guilhot, F. , et al. (2011). Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor *. Journal of Biological Chemistry, 286.


Specifications

  • Immunogen
  • IL-6R bound to Sepharose4B.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • ELISA, FC, IP, FuncS, IF, Neut, ICC
  • Trade name
  • tocilizumab, tocilizumab
  • CAS
  • 375823-41-9
  • Generic Name
  • tocilizumab/Atlizumab
  • Biological Half-Life
  • 8–14 days during steady state (dependent on concentration)
  • ATC Code
  • L04AC07
  • UNII
  • I031V2H011
  • ChEMBL
  • CHEMBL1237022
  • MW
  • 145.0 kDa

Applications

  • Application Notes
  • The IL6R antibody has been reported in applications of Inhib.

Target

  • Alternative Names
  • tocilizumab/Atlizumab;tocilizumab, rotocilizumab;375823-41-9;atlizumab;tocilizumab ;Rotocilizumab;IL6R;interleukin 6 receptor;interleukin-6 receptor subunit alpha;CD126;IL-6R 1;CD126 antigen;membrane glycoprotein 80;IL-6 receptor subunit alpha;gp80;IL6RA;IL-6RA;IL-6R-1;M

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Tocilizumab/Atlizumab.
Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Tocilizumab/Atlizumab.

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Afuco™ Anti-IL6R ADCC Therapeutic Antibody (Tocilizumab/Atlizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL6R. Tocilizumab (INN, or atlizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

See other products for "IL6R"


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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