lnterleukin-1 beta (IL-1 B), also known as catabolin, is a cytokine protein. IL-1 B is a member of the interleukin 1 family of cytokines and is also described as interleukin 1, beta; IL-1 b; IL-1 β; IL1 -BETA; IL1 F2. Anti-IL-1 B antagonist molecules, in particular anti-IL-1 B antagonist molecules, which have high binding affinity to IL-1 B. It can be used as therapeutic agents to treat diseases, in particular respiratory diseases in humans.
Figure 1 IL1B inhibits gastrin expression in AGS cells.
Treatment of AGS cells with increasing amount of recombinant IL1B protein for 2 h caused gradual decrease in endogenous gastrin as measured by ELISA.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
Figure 2 Time course analysis of IKβ degradation in IL1B treated AGS cells.
One representative of at least three independent experiments with similar results is shown.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
Figure 3 Release of IL1B mediated inhibition of gastrin expression by NFB inhibitor TPCK in AGS cells.
Cells were lysed and ELISA measured gastrin protein expression.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1235z | Mouse Anti-IL1B Recombinant Antibody (clone 20C12) | ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
PABC-082 | Mouse Anti-IL1B Recombinant Antibody (clone YC128) | WB, ELISA | Mouse IgG |
PABL-608 | Human Anti-IL1B Recombinant Antibody (clone ACZ885) | Neut | Human IgG |
HPAB-0330-FY | Mouse Anti-IL1B Recombinant Antibody (clone 048-Ab-1) | In vivo, ELISA | Mouse IgG |
HPAB-0331-FY | Mouse Anti-IL1B Recombinant Antibody (clone 048-Ab-3) | In vivo, ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-021 | Anti-Human IL1Beta Recombinant Antibody (Canakinumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
TAB-550LC-S(P) | Anti-human IL1B scFv Fragment (9.5.2) | ELISA | Human antibody |
TAB-551LC-S(P) | Anti-human IL1B scFv Fragment (5.5.1) | ELISA | Human antibody |
TAB-552LC-S(P) | Anti-human IL1B scFv Fragment (8.18.1) | ELISA | Human antibody |
TAB-553LC-S(P) | Anti-human IL1B scFv Fragment (6.20.1) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-603 | Human Anti-IL1B Recombinant Antibody (clone ACZ885); Fab Fragment | Neut | Human Fab |
HPAB-0729-FY-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0729-FY-S(P)) | ELISA, Neut | Mouse scFv |
HPAB-0730-FY-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0730-FY-S(P)) | ELISA, Neut | Mouse scFv |
HPAB-0858-FY-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0858-FY-S(P)) | Neut | Humanized scFv |
HPAB-0859-FY-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0859-FY-S(P)) | Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-082 | Mouse Anti-IL1B Recombinant Antibody (clone YC128); scFv Fragment | WB, ELISA | Mouse scFv |
HPAB-1559-FY-F(E) | Mouse Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-1559-FY-F(E)) | ELISA | Mouse Fab |
HPAB-1171WJ-S(P) | Mouse Anti-IL1B Recombinant Antibody (clone MU007); scFv Fragment | ELISA | Mouse scFv |
HPAB-1172WJ-S(P) | Recombinant Human Anti-IL1B Antibody scFv Fragment (HU007) | ELISA | Humanized scFv |
HPAB-1266WJ-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-1266WJ-S(P)) | ELISA, WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-230CT | Mouse Anti-IL1B Recombinant Antibody (TAB-230CT) | ELISA | Mouse IgG |
TAB-231CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (47F11) | Inhibition | |
TAB-234CT | Rabbit Anti-IL1B Recombinant Antibody (TAB-234CT) | FC, ELISA, Neut | Rabbit IgG |
TAB-235CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (SK48-E26) | ELISA, Neut | |
TAB-230CT-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-230CT-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-233CT | Human Anti-IL1B Recombinant Antibody (TAB-233CT) | IF | Humanized IgG |
TAB-236CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (huSK48-E26) | ELISA, Neut | Humanized antibody |
TAB-233CT-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-233CT-S(P)) | ELISA | Humanized scFv |
TAB-236CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
TAB-544LC | Anti-human IL1B Recombinant Antibody, Humanized (TAB-544LC) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-232CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (ch47F11) | Inhibition | Chimeric antibody (mouse/human) |
TAB-237CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (chSK48-E26) | ELISA, Neut | Chimeric antibody (mouse/human) |
TAB-543LC | Anti-human IL1B Recombinant Antibody, Chimeric (TAB-543LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-543LC-S(P) | Anti-human IL1B scFv Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
TAB-543LC-F(E) | Anti-human IL1B Fab Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0282MZ | Chicken Anti-Interleukin-1β Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1271CQ | Recombinant Mouse Anti-IL1B Antibody (CBL665) | Neut | IgG1 |
NEUT-1272CQ | Mouse Anti-IL1B Recombinant Antibody (clone 4M27) | IHC, Neut, WB | Mouse IgG2 |
NEUT-1273CQ | Mouse Anti-IL1B Recombinant Antibody (clone 8516.311) | ELISA, WB, Neut | Mouse IgG1 |
NEUT-1275CQ | Mouse Anti-IL1B Recombinant Antibody (clone 2805R) | ELISA, Neut, WB, ICC | Mouse IgG1 |
NEUT-1276CQ | Mouse Anti-IL1B Recombinant Antibody (clone CBL697) | Neut, ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1274CQ | Mouse Anti-IL1B Recombinant Antibody (clone B-A15) | Block, FC | Mouse IgG1 |
NEUT-1285CQ | Mouse Anti-IL1B Recombinant Antibody (clone H1b-27) | ELISA, ELISPOT, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1798 | Rabbit Anti-IL1B Recombinant Antibody (clone DS1798AB) | WB | Rabbit IgG |
MOR-4237 | Rabbit Anti-IL1B Recombinant Antibody (clone SI316DS) | ELISA | Rabbit IgG |
MOR-4238 | Rabbit Anti-IL1B Recombinant Antibody (clone SI317DS) | ELISA | Rabbit IgG |
MOR-4239 | Rabbit Anti-IL1B Recombinant Antibody (clone SI318DS) | ELISA | Rabbit IgG |
MOR-4605 | Rabbit Anti-IL1B Recombinant Antibody (clone TH118DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-021 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-161 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Gevokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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