Anti-Lewis Y Recombinant Antibody (BR55-2) (CAT#: TAB-0018CL)
Antibody BR55-2 is a mouse monoclonal antibody against Y oligosaccharide. It can bind to human LeY expressing tumor cells.
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Activ
Figure 1 Anti-Lewis Y monoclonal antibody BR55-2 induced caspase-3/7 activation in HCC1954.
HCC1954 (A) or MCF-7 (B) cells were incubated with various concentrations of BR55-2 and, after 24 hours of incubation, caspase-3 activity was measured. Two-way ANOVA with Bonferroni post-test was performed and P values are shown. Bar heights ± error bars denote means ± SDs of three technical replicates.
Hutchins, L. F., Makhoul, I., Emanuel, P. D., Pennisi, A., Siegel, E. R., Jousheghany, F., ... & Kieber-Emmons, T. (2017). Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects. Oncotarget, 8(58), 99161.
Inhib
Figure 2 Anti-Lewis Y monoclonal antibody BR55-2 induced caspase-3/7 growth inhibition in HCC1954.
The effect of BR55-2 on cell survival was measured after 24 (A) and 48 (B) hours of incubation using CCK-8 kit. Symbols ± error bars at each tested antibody concentration denote means ± SDs of three technical replicates. BR55-2 negatively affected viability of HCC1954 cells at all concentrations after 24 and 48 hours (P < 0.001), while no statistically signicant growth inhibition was observed in MCF-7 cells (P> 0.05).
Hutchins, L. F., Makhoul, I., Emanuel, P. D., Pennisi, A., Siegel, E. R., Jousheghany, F., ... & Kieber-Emmons, T. (2017). Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects. Oncotarget, 8(58), 99161.
Specifications
- Host Species
- Mouse
- Clone
- BR55-2
- Applications
- Activ, Inhib
- Related Disease
- LeY expressing tumors
Applications
- Application Notes
- This antibody has been reported for use in Activation and Inhibition.
Target
- Alternative Names
- Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis(y) antigen; Lewis(y)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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