Human Anti-Lewis Y (clone MB311) scFv-Fc Chimera (CAT#: VS-0325-FY131)
This antibody fragment is engineered for highly specific targeting of cancer cells. It features a single-chain variable fragment (scFv) that specifically binds to the Lewis Y (Ley) antigen, a carbohydrate molecule frequently found on the surface of various epithelial tumors.
To enhance its stability and functionality, the scFv is linked to an Fc region (derived from human immunoglobulin) via a flexible connector, forming a single, continuous polypeptide chain. This design results in a bivalent antibody, capable of binding two Ley antigens at the same time. This bivalent binding can potentially increase its overall binding strength (avidity) to tumor cells, which is important for therapeutic and diagnostic applications.
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It is designed to specifically bind to the Lewis Y antigen.
- Species Reactivity
- Human
- Clone
- MB311
- Applications
- ADCC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- LeY, CD174
- Long Name
- Lewis Y antigen
- Function
- Human Lewis Y is a tetrasaccharide antigen expressed on various cell surfaces, including epithelial cells and tumor cells. It functions in cell adhesion and is a target for cancer therapy.
Recommended Products
Isotype Control
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Hexamer Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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