Human Anti-Lewis Y (clone MB311) scFv-Fc Chimera
CAT#: VS-0325-FY131
This antibody fragment is engineered for highly specific targeting of cancer cells. It features a single-chain variable fragment (scFv) that specifically binds to the Lewis Y (Ley) antigen, a carbohydrate molecule frequently found on the surface of various epithelial tumors.
To enhance its stability and functionality, the scFv is linked to an Fc region (derived from human immunoglobulin) via a flexible connector, forming a single, continuous polypeptide chain. This design results in a bivalent antibody, capable of binding two Ley antigens at the same time. This bivalent binding can potentially increase its overall binding strength (avidity) to tumor cells, which is important for therapeutic and diagnostic applications.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It is designed to specifically bind to the Lewis Y antigen.
- Species Reactivity
- Human
- Clone
- MB311
- Applications
- ADCC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- LeY, CD174
- Long Name
- Lewis Y antigen
- Function
- Human Lewis Y is a tetrasaccharide antigen expressed on various cell surfaces, including epithelial cells and tumor cells. It functions in cell adhesion and is a target for cancer therapy.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone MB311"
- CAT
- Product Name
See other products for "Lewis Y"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0018CL | Anti-Lewis Y Recombinant Antibody (BR55-2) | Activ, Inhib | |
| TAB-0018CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (BR55-2) | FuncS, Inhib | |
| TAB-0650CL-F(E) | Anti-Human Lewis Y Recombinant Antibody Fab Fragment (3S193) | ELISA | |
| PABX-131 | Recombinant Mouse Anti-LewisY Antibody (MBR96) | WB, Neut, FuncS | IgG |
| PABX-131-S (P) | Recombinant Mouse Anti-LewisY Antibody scFv Fragment (MBR96) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0015CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (MB311) | FC | Humanized Antibody |
| TAB-0016CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (Hu3s193) | ELISA, BI | Humanized Antibody |
| TAB-0017CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (hABL364) | ELISA | Humanized Antibody |
| TAB-0019CL-F(E) | Human Anti-Lewis Y Recombinant Antibody; Fab Fragment (TAB-0019CL-F(E)) | FuncS | Humanized Fab |
| PABX-003-F (E) | Recombinant Human Anti-LewisY Antibody Fab Fragment (hu3S193) | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-044LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-103LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-003-S (P) | Recombinant Human Anti-LewisY Antibody scFv Fragment (hu3S193) | WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5) | ELISA, FC, IHC | Mouse IgG |
| FAMAB-1327CQ | Human Anti-Lewis Y Recombinant Antibody (clone BR96) | IHC, Cyt | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-F(E) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); Fab Fragment | FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-S(P) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); scFv Fragment | FC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC135 | Human Anti-Lewis Y Recombinant Antibody Hexamer (VS-0924-YC135), CDC Enhanced | CDC, ADCC, ELISA | Antibody hexamer |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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