Anti-Human Lewis Y Recombinant Antibody (MB 311) (CAT#: TAB-488CL)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human Lewis Y. MB311 is a fully humanized monoclonal antibody recognizing the tumor-associated antigen Lewis Y. This carbohydrate antigen is expressed on 60-90 % of all epithelial cancers, with only limited expression on normal tissues, and thus represents an attractive target for cancer immunotherapy. MB311 was well tolerated, permeated into malignant effusion and attracted immune cells leading to decreased tumor cell counts in the effusion.
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Cyt
Figure 1 Pharmacokinetics (Titer) and Pharmacodynamics (CDC and ADCC) of MB311.
Bauernhofer, T., Samonigg, H., Regitnik, P., Weitzer, W., Lileg, B., Waxenecker, G., ... & Fido, M. (2013). Safety and therapeutic efficacy of the Lewis Y carbohydrate specific humanized antibody MB311 in patients with malignant effusion. Journal of Cancer Therapy, 2014.
Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Cyt
- Related Disease
- Cancer
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Applications
- Application Notes
- This antibody has been tested for use in Cytotoxicity. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis(y) antigen; Lewis(y)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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