Recombinant Humanized monoclonal antibody expressed in CHO binding to Human Lewis Y. MB311 is a fully humanized monoclonal antibody recognizing the tumor-associated antigen Lewis Y. This carbohydrate antigen is expressed on 60-90 % of all epithelial cancers, with only limited expression on normal tissues, and thus represents an attractive target for cancer immunotherapy. MB311 was well tolerated, permeated into malignant effusion and attracted immune cells leading to decreased tumor cell counts in the effusion.
Figure 1 Pharmacokinetics (Titer) and Pharmacodynamics (CDC and ADCC) of MB311.
Bauernhofer, T., Samonigg, H., Regitnik, P., Weitzer, W., Lileg, B., Waxenecker, G., ... & Fido, M. (2013). Safety and therapeutic efficacy of the Lewis Y carbohydrate specific humanized antibody MB311 in patients with malignant effusion. Journal of Cancer Therapy, 2014.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-730 | Humanized Anti-Lewis Y Recombinant Antibody (clone CBR96) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Humanized (from mouse) IgG1, κ |
TAB-0015CL | Anti-Lewis Y Recombinant Antibody (MB311) | FC, FuncS | Humanized Antibody |
TAB-0016CL | Anti-Lewis Y Recombinant Antibody (Hu3s193) | RIA, IHC | Humanized Antibody |
TAB-0017CL | Anti-Lewis Y Recombinant Antibody (hABL364) | CDC, ADCC, ELISA | Humanized Antibody |
TAB-0019CL | Human Anti-Lewis Y Recombinant Antibody (TAB-0019CL) | FC, FuncS | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0018CL | Anti-Lewis Y Recombinant Antibody (BR55-2) | Activ, Inhib | |
TAB-0650CL-S(P) | Anti-Human Lewis Y Recombinant Antibody scFv Fragment (3S193) | ELISA | |
TAB-0018CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (BR55-2) | FuncS, Inhib | |
TAB-0650CL-F(E) | Anti-Human Lewis Y Recombinant Antibody Fab Fragment (3S193) | ELISA | |
PABX-131 | Recombinant Mouse Anti-LewisY Antibody (MBR96) | WB, Neut, FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-044LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-045LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-103LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-003-S (P) | Recombinant Human Anti-LewisY Antibody scFv Fragment (hu3S193) | WB, IF, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0207CQ | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5) | ELISA, FC, IHC | Mouse IgG |
FAMAB-1327CQ | Human Anti-Lewis Y Recombinant Antibody (clone BR96) | IHC, Cyt | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0207CQ-F(E) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); Fab Fragment | FC, IHC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0207CQ-S(P) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); scFv Fragment | FC, IHC | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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