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Humanized Anti-MET Recombinant Antibody (clone Onartuzumab (OA5D5.v2)); scFv Fragment (CAT#: PFBZ-155)

Recombinant Humanized Antibody (Onartuzumab (OA5D5.v2)) Fab Fragment is specific to MET. Onartuzumab, derived from the 5D5 antibody previously shown to bind the MET Sema domain, has shown preclinical activity in glioblastoma (GBM), pancreatic cancer, and non–small-cell lung cancer (NSCLC), among other tumor types.


See more Engineered Antibody products for MET
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  • Gene Expression
  • Datasheet
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

Specifications

  • Immunogen
  • Human MET proto-oncogene, receptor tyrosine kinase
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Human Fab
  • Specificity
  • Tested positive against MET
  • Species Reactivity
  • Human
  • Clone
  • Onartuzumab (OA5D5.v2)
  • Applications
  • ELISA, Neut

Product Property

  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Target

  • Alternative Names
  • MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase;

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G049E Anti-MET immunotoxin (Fab)-PE Cytotoxicity assay, Function study

Recombinant Antibody

CAT Product Name Application Type
PABL-271 Human Anti-MET Recombinant Antibody (clone 5D5) WB, Block, FuncS Human IgG
HPAB-0123-FY Camelid Anti-MET Recombinant Antibody (HPAB-0123-FY) ELISA Llama IgG1, λ
HPAB-0030-WJ Human Anti-MET Recombinant Antibody (HPAB-0030-WJ) ELISA, WB Human IgG
HPAB-1298LY Human Anti-MET Recombinant Antibody (HPAB-1298LY) ELISA, IP Human IgG2
HPAB-1299LY Human Anti-MET Recombinant Antibody (HPAB-1299LY) ELISA, IP Human IgG2

ADCC Enhanced Antibody

CAT Product Name Application Type
PABZ-155 Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced ELISA, Neut ADCC enhanced antibody
AFC-TAB-H24 Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody

Humanized Antibody

CAT Product Name Application Type
TAB-0332CL-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) ELISA Humanized scFv
TAB-0881CLV-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0881CLV-S(P)) ELISA, FuncS Humanized scFv
TAB-0883CLV-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0883CLV-S(P)) ELISA, FuncS Humanized scFv
TAB-0884CLV-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0884CLV-S(P)) ELISA, FuncS Humanized scFv
TAB-0885CLV-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0885CLV-S(P)) ELISA, FuncS Humanized scFv

Chimeric Antibody

CAT Product Name Application Type
TAB-002MZ Anti-Human MET Recombinant Antibody (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-S(P) Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-0880CLV Human Anti-MET Recombinant Antibody (TAB-0880CLV) ELISA, FuncS Chimeric (mouse/human) IgG1
TAB-0880CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) ELISA, FuncS Chimeric (mouse/human) Fab

Mouse Antibody

CAT Product Name Application Type
TAB-011MZ Mouse Anti-MET Recombinant Antibody (TAB-011MZ) ELISA, WB, FC Mouse IgG
TAB-012MZ Mouse Anti-MET Recombinant Antibody (TAB-012MZ) ELISA, WB, FC Mouse IgG
TAB-027MZ Mouse Anti-MET Recombinant Antibody (TAB-027MZ) WB, IP, IF Mouse lgG1
TAB-028MZ Mouse Anti-MET Recombinant Antibody (TAB-028MZ) IP Mouse lgG1
TAB-029MZ Mouse Anti-MET Recombinant Antibody (TAB-029MZ) IP, WB Mouse lgG1

Human Antibody

CAT Product Name Application Type
TAB-034MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-1-A1) WB, ELISA Human antibody
TAB-035MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-A9) WB, ELISA Human antibody
TAB-036MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-A11) WB, ELISA Human antibody
TAB-037MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-B2) WB, ELISA Human antibody
TAB-038MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-4-A5) WB, ELISA Human antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1726CQ Recombinant Rabbit Anti-MET Antibody (CBL1008) Neut IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2216 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) ICC/IF, IHC-P, WB IgG
MOR-4519 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) WB, IF, ICC IgG
MOR-4645 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) WB, IF, ICC, FC, ELISA IgG
MOR-4694 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) WB, ELISA IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-1298LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) ELISA, IP Human Fab
HPAB-1299LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) ELISA, IP Human Fab
HPAB-1300LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) ELISA, IP Human Fab
HPAB-1301LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) ELISA, IP Human Fab
HPAB-1302LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E)) ELISA, IP Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-M0277-YC-S(P) Human Anti-MET Recombinant Antibody (clone ch3E1D7); scFv Fragment ELISA, Neut Human scFv
HPAB-0714-FY-F(E) Mouse Anti-MET Recombinant Antibody (clone AB013); scFv Fragment ELISA Mouse scFv
HPAB-1309-FY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1309-FY-F(E)) ELISA Human Fab
HPAB-1310-FY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1310-FY-F(E)) ELISA Human Fab
HPAB-1579-FY-F(E) Human Anti-MET Recombinant Antibody (clone MET021); scFv Fragment WB, ELISA Human scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF474 A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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