Recombinant Anti-SNCA VHH Single Domain Antibody (PNBL-086)
CAT#: PNBL-086
Anti-Human SNCA VHH Single Domain Antibody is a recombinant protein produced in E. coli.
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
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Specifications
- Host Species
- Llama
- Derivation
- Llama
- Type
- Llama VHH
- Species Reactivity
- Human
- Clone
- PNBL-086
- Applications
- Can be useful in applications such as: Western Blot, Functional Study
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
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Remarkable Sensitivity
We used the anti-SNCA antibody in our Western Blot assays and were thoroughly impressed. The antibody's ability to detect even the minute amounts of alpha-synuclein highlights its remarkable sensitivity. The results we obtained were clear and highly reproducible, contributing positively to our ongoing research in alpha-synuclein-related pathologies.
Enhances Experimental Outcomes
We integrated this antibody into our protein structural studies, and it has greatly facilitated our understanding of SNCA conformational dynamics. The stability of the antibody ensures that our experiments yield reliable and significant outcomes, providing valuable insights into potential therapeutic interventions for synucleinopathies.
Reliable Research Partner
I've been using the Anti-SNCA Single Domain Antibody for functional studies related to Parkinson's disease, and it has proven to be highly reliable. Its sensitivity and specificity are unmatched, providing consistent results that enhance the credibility of our research findings. The antibody's stability during experiments is remarkable, and its animal-free production aligns with ethical research standards, making it an essential tool in our lab.
Q&As
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What protein target does this antibody bind to, and why is this important?
A: The antibody specifically binds to SNCA, also known as alpha-synuclein. This is important because misfolded SNCA is involved in several neurological diseases, including Parkinson's and Alzheimer's, offering insights into therapeutic intervention points and pathology.
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What applications can be performed using the Anti-SNCA Single Domain Antibody?
A: This antibody is ideal for applications like Western Blot and functional studies due to its high specificity and sensitivity. It allows researchers to detect and analyze proteins involved in various pathways and interactions within cells, crucial for understanding cellular mechanisms and disease processes.
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How does the Anti-SNCA Antibody contribute to Parkinson's disease research?
A: The antibody targets alpha-synuclein (SNCA), a protein crucially implicated in Parkinson's disease. Abnormal aggregation of SNCA is a hallmark of neurodegenerative disorders. This antibody helps study these aggregates, aiding in the understanding of disease mechanisms and the development of therapeutic strategies.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PNBL-086, RRID: AB_3111725)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "SNCA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(A) | Recombinant Anti-human SNCA Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0741CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0742CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0742CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0743CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0743CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0744CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0744CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0745CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0745CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC, IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-005CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| NS-088CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-088CN-F(E)) | WB, ELISA, IHC | Mouse Fab |
| HPAB-N0389-YC-F(E) | Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0389-YC-F(E)) | ELISA, IP, FuncS | Human Fab |
| HPAB-N0390-YC-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0390-YC-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-0753-WJ-F(E) | Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-0753-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-005CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| NS-088CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-088CN-S(P)) | WB, ELISA, IHC | Mouse scFv |
| FAMAB-0260-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone D10); scFv Fragment | ELISA | Human scFv |
| HPAB-N0389-YC-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0389-YC-S(P)) | ELISA, IP, FuncS | Human scFv |
| HPAB-N0390-YC-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0390-YC-S(P)) | ELISA, IP, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0572U | Rabbit Anti-Phospho-SNCA (S129) Recombinant Antibody (clone 4G3) | ELISA, IHC, IF | Rabbit IgG |
| ZG-0573U | Rabbit Anti-SNCA Recombinant Antibody (clone 5E5) | ELISA, IHC | Rabbit IgG |
| VS3-QX1037 | Mouse Anti-SNCA Recombinant Antibody (clone 9H12) | ELISA | Mouse IgG1 |
| VS7-0425-WR897 | Mouse Anti-SNCA Monoclonal Antibody (clone 2B2D1) | IHC | Mouse IgG1 |
| VS7-0425-WR898 | Mouse Anti-SNCA Monoclonal Antibody (VS7-0425-WR898) | WB, IHC-P, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY244 | AbPlus™ Anti-SNCA Magnetic Beads (JB42-33) | IP, Protein Purification | |
| VS-0724-YC791 | AbPlus™ Anti-SNCA Magnetic Beads (VS-0724-YC791) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY32 | Human Anti-SNCA scFv-Fc Chimera (VS-0325-FY32) | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2129 | Anti-SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6773 | Anti-Mouse SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6772 | Anti-Human SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6774 | Anti-Rat SNCA Immunohistochemistry Kit | IHC |
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