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    Recombinant Anti-human SNCA Intrabody [(D-Arg)9] (CAT#: IAB-B031(A))

    Recombinant anti-SNCA intrabody linked to (D-Arg)9 works within cells to bind human monomeric wild-type SNCA, expressed in E. coli cells. The intrabody stabilizes detergent-soluble monomeric syn and inhibits the formation of detergent-insoluble high-molecular-weight syn species. In addition, the intrabody ameliorates the decreased cell adhesion that characterizes the syn-overexpressing cells. Anti-SNCA intrabodies may represent novel molecular therapeutics for synucleinopathies, with implications for other neurodegenerative disorders caused by misfolded accumulated proteins.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 High expression in cerebral cortex
    Figure 1 High expression in cerebral cortex
    (Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
    Figure 3 Kidney
    Figure 3 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
    Figure 4 Testis
    Figure 4 Testis
    (Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
    Figure 5 Bone marrow
    Figure 5 Bone marrow
    (Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
    Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA

    Specifications

    • Immunogen
    • human synuclein, alpha (non A4 component of amyloid precursor)
    • Host Species
    • human
    • Type
    • scFv-(D-Arg)9
    • Cell Penetrating Peptide
    • (D-Arg)9
      It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
    • Species Reactivity
    • human
    • Applications
    • Antibody assay: Flow Cytometry; Immunofluorescence; Functional studies

    Product Property

    • Purity
    • >95%, by SDS-PAGE, under reducing conditions
    • Storage
    • Store at -20°C. Open under aseptic conditions.

    Target

    • Alternative Names
    • SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    CAT Product Name Application Type
    IAB-B031(G) Recombinant Anti-human SNCA Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
    IAB-B031(T) Recombinant Anti-human SNCA Intrabody [Tat] ELISA, IF, Neut, FuncS scFv-Tat

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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