Recombinant Anti-human SNCA Intrabody [(D-Arg)9]
CAT#: IAB-B031(A)
Recombinant anti-SNCA intrabody linked to (D-Arg)9 works within cells to bind human monomeric wild-type SNCA, expressed in E. coli cells. The intrabody stabilizes detergent-soluble monomeric syn and inhibits the formation of detergent-insoluble high-molecular-weight syn species. In addition, the intrabody ameliorates the decreased cell adhesion that characterizes the syn-overexpressing cells. Anti-SNCA intrabodies may represent novel molecular therapeutics for synucleinopathies, with implications for other neurodegenerative disorders caused by misfolded accumulated proteins.
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
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Specifications
- Immunogen
- human synuclein, alpha (non A4 component of amyloid precursor)
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Antibody assay: Flow Cytometry; Immunofluorescence; Functional studies
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "SNCA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-086 | Recombinant Anti-SNCA VHH Single Domain Antibody (PNBL-086) | WB, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0741CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0742CLV-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0742CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0743CLV-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0743CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0744CLV-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0744CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0745CLV-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0745CLV-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC, IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-005CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| NS-088CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-088CN-F(E)) | WB, ELISA, IHC | Mouse Fab |
| HPAB-653-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-653-FY-F(E)) | WB, IP, ELISA | Mouse Fab |
| HPAB-654-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-654-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0753-WJ-F(E) | Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-0753-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-005CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| NS-088CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-088CN-S(P)) | WB, ELISA, IHC | Mouse scFv |
| HPAB-0023-FY-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-0023-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-N0389-YC-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0389-YC-S(P)) | ELISA, IP, FuncS | Human scFv |
| HPAB-N0390-YC-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0390-YC-S(P)) | ELISA, IP, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0260-CN | Human Anti-SNCA Recombinant Antibody (clone D10) | ELISA | Human IgG |
| FAMAB-0261-CN | Human Anti-SNCA Recombinant Antibody (clone 6E) | ELISA | Human IgG |
| VS3-WK1796 | Recombinant Rabbit Anti-SNCA Capture Antibody (clone R85-8W-7) | ELISA | Rabbit IgG |
| VS3-WK1797 | Recombinant Rabbit Anti-SNCA Detection Antibody (clone R55-3F-1) | ELISA | Rabbit IgG |
| VS3-WK1798 | Recombinant Rabbit Anti-Mouse SNCA Capture Antibody (clone R59-4X-6) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY244 | AbPlus™ Anti-SNCA Magnetic Beads (JB42-33) | IP, Protein Purification | |
| VS-0724-YC791 | AbPlus™ Anti-SNCA Magnetic Beads (VS-0724-YC791) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY32 | Human Anti-SNCA scFv-Fc Chimera (VS-0325-FY32) | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2129 | Anti-SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6773 | Anti-Mouse SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6772 | Anti-Human SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6774 | Anti-Rat SNCA Immunohistochemistry Kit | IHC |
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