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SNCA
Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha).
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Melanocytes, Excitatory neurons, Oligodendrocytes)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
Interaction
Soluble monomer. Homotetramer (PubMed:21841800). A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (PubMed:21841800). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm (PubMed:19762560). Interacts with CALM1 (PubMed:23607618). Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation (PubMed:27597756). Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (PubMed:20798282). Interacts with RPH3A and RAB3A (PubMed:15207266). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (PubMed:22854022, PubMed:31034892). Interacts with SEPTIN4 (By similarity).
More Types Infomation
- Mouse Anti-SNCA Recombinant Antibody (clone 8F8) (MOB-1365z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, ICC, IF, WB
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- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, FuncS
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: FC, WB, ICC/IF
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- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, ICC, IHC-P, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC, ICC, FC, IP
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, FuncS, WB
- Human Anti-SNCA Recombinant Antibody (clone D10); scFv Fragment (FAMAB-0260-CN-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Recombinant Human Anti-SNCA Antibody (NAC32) (NEUT-1977CQ)
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- Species Reactivity: Human
- Type: IgG1, κ
- Application: IHC, WB, BL
- Human Anti-SNCA Recombinant Antibody (clone D10) (FAMAB-0260-CN)
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-SNCA Recombinant Antibody (clone 6E) (FAMAB-0261-CN)
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-SNCA Recombinant Antibody (clone D10); Fab Fragment (FAMAB-0260-CN-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-SNCA Recombinant Antibody (clone 6E); Fab Fragment (FAMAB-0261-CN-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Human Anti-SNCA Recombinant Antibody (clone 6E); scFv Fragment (FAMAB-0261-CN-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0746CLV-F(E)) (TAB-0746CLV-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0745CLV-F(E)) (TAB-0745CLV-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0744CLV-F(E)) (TAB-0744CLV-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0743CLV-F(E)) (TAB-0743CLV-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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