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Anti-TFRC immunotoxin 454A12 (IgG)-Gel (AGTO-G068G)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating leptomeningeal carcinomatosis.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
454A12
Molecule Class
IgG-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Leptomeningeal carcinomatosis
Target
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1
Entrez Gene ID
7037
UniProt ID
P02786

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Anti-Human TfR Therapeutic Antibody scFv Fragment (7A4)    ( TAB-612CT-S(P) )
Anti-Human TfR Therapeutic Antibody Fab Fragment (C3.2)    ( TAB-626CT-F(E) )
Anti-Human TfR Therapeutic Antibody Fab Fragment (PPMXT001)    ( TAB-619CT-F(E) )
Afuco™ Anti-Human TFRC ADCC Theraputic Antibody, ADCC Enhanced    ( AFC-581CL )
Anti-Human TfR Therapeutic Antibody Fab Fragment (3TG9)    ( TAB-627CT-F(E) )
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