Creative Biolabs Recombinant Antibodies
Products
  1. Home
  2. TFRC
  3. Anti-TFRC immunotoxin 454A12 (IgG)-Sap

Anti-TFRC immunotoxin 454A12 (IgG)-Sap (AGTO-G068S)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of leptomeningeal carcinomatosis.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
454A12
Molecule Class
IgG-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Leptomeningeal carcinomatosis
Target
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1
Entrez Gene ID
7037
UniProt ID
P02786

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "TFRC"
Anti-TfR Antibody-Cytokine Fusion Protein, IgG (ch17217)-GM-CSF    ( ACFP-SH022 )
Anti-Human TfR Therapeutic Antibody (15G11)    ( TAB-611CT )
Recombinant Rat Anti-Mouse TFRC Antibody scFv Fragment (9E4)    ( CBMAB-035LC-S(P) )
Anti-Human TfR Therapeutic Antibody Fab Fragment (3TF12)    ( TAB-623CT-F(E) )
Recombinant Mouse Anti-TFRC Antibody Fab Fragment (15G11)    ( HPAB-0376-CN-F(E) )
Anti-Human TfR Therapeutic Antibody Fab Fragment (3TF2)    ( TAB-624CT-F(E) )
Anti-Human TfR Therapeutic Antibody Fab Fragment (55-31)    ( TAB-616CT-F(E) )
Anti-Human TFRC Therapeutic Antibody scFv Fragment (B84)    ( TAB-0467CL-S(P) )
>> MORE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Verification code

Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
        

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved