Anti-TFRC immunotoxin 454A12 (IgG)-Sap (CAT#: AGTO-G068S)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of leptomeningeal carcinomatosis.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • 454A12
  • Molecule Class
  • IgG-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Leptomeningeal carcinomatosis

Target

  • Alternative Names
  • TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); saporin; saporin-6; saporin-S65; SAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Recombinant Antibody

CAT Product Name Application Type
MOB-1176z Mouse Anti-TFRC Recombinant Antibody (MOB-1176z) ELISA, WB, IP, IF, IHC, FC Mouse IgG1, κ
MOB-035LC Rat Anti-TFRC Recombinant Antibody (clone 9E4) FuncS, IHC, FC Rat IgG
MRO-1758-CN Rabbit Anti-TFRC Polyclonal Antibody (MRO-1758-CN) IF, IHC, FC Rabbit IgG
HPAB-0238-YJ Rat Anti-TFRC Recombinant Antibody (HPAB-0238-YJ) IHC, FC, WB, FuncS Rat IgG2a
HPAB-0239-YJ Mouse Anti-TFRC Recombinant Antibody (HPAB-0239-YJ) IHC, FC, WB, FuncS Chimeric (mouse/rat) IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-L076E transferrin-PE immunotoxin Cytotoxicity assay, Functional assay
AGTO-L076R transferrin-RTA immunotoxin Cytotoxicity assay, Functional assay

Blocking Antibody

CAT Product Name Application Type
NEUT-1999CQ Rat Anti-Tfrc Recombinant Antibody (clone RI7217) FC, ICC, IP, WB, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3548 Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) FC, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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