What is the target of this fully human antibody?

This fully human recombinant antibody (clone 2C5) targets TNFSF13B, also known as BLyS or BAFF. It cross-reacts with mouse and cynomolgus BLyS.

What application is this antibody recommended for?

The antibody has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA). It is capable of supporting B-cell survival and differentiation research.

Anti-Human TNFSF13B Recombinant Antibody (2C5)

CAT#: TAB-1166CL

The anti-BlyS antibody targets BLyS also known as BAFF, which is a homologous TNF-like cytokine that supports the survival and differentiation of B-cells. The antibody can be used in the treatment and prevention of inflammatory and immune diseases, such as systemic lupus erythramatous.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line THP-1

Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg

Normal Tissue Figure 5 Colon

Peripheral nerve/ganglion
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg

Normal Tissue Figure 9 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

❮

❯

Specifications

Host Species
Human

Type
Fully human antibody

Specificity
Human

Species Reactivity
Cross-react with mouse BLyS and cynomolgus BLyS

Clone
2C5

Related Disease
Systemic lupus erythramatous

Target

Alternative Names
TNFSF13B; THANK; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; BAFF; TNF- And APOL-Related Leukocyte Expressed Ligand 1; B-Cell-Activating Factor; Tumor Necrosis Factor Ligand Superfamily Member 13B; BLYS

Gene ID
10673

UniProt ID
Q9Y275

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Breast cancer biomarkers at key points during disease progression

Targets BLyS Effectively

The anti-TNFSF13B antibody (clone 2C5) is a robust reagent for targeting BLyS (BAFF). We used it in ELISA, and it showed strong binding to human BLyS as well as cross-reactivity with mouse and cynomolgus homologs.

High Quality Human Antibody

This fully human recombinant antibody is of exceptional quality. It is stable and performs consistently in our assays investigating B-cell survival. The specific binding to BLyS allows us to study the regulation of humoral immunity precisely.

Q&As

What is the target of this fully human antibody?

A: This fully human recombinant antibody (clone 2C5) targets TNFSF13B, also known as BLyS or BAFF. It cross-reacts with mouse and cynomolgus BLyS.
What application is this antibody recommended for?

A: The antibody has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA). It is capable of supporting B-cell survival and differentiation research.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-1166CL.pdf

MSDS

MSDS - TAB-1166CL.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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