Human Anti-TSHR Recombinant Antibody (clone K1-70); Fab Fragment (CAT#: PFBL-730)
Recombinant Human Antibody (K1-70) Fab Fragment is specific to TSH receptor (TSHR), expressed in Chinese Hamster Ovary cells (CHO). The blocking autoantibody Fab fragment binds more N-terminally on the TSHR concave surface than either the stimulating autoantibody M22 or the hormone TSH, and this may reflect its different functional activity.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
Figure 2 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_A_6_6.jpg
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000165409-TSHR
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000165409-TSHR
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165409-TSHR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165409-TSHR
Specifications
- Immunogen
- Human thyroid stimulating hormone receptor
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human TSHR
- Species Reactivity
- Human
- Clone
- K1-70
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Please select product type
scFv Fragment Antibody
Fab Fragment Antibody
Recombinant Antibody
Mouse Antibody
Human Antibody
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-353 | Mouse Anti-TSHR Recombinant Antibody (clone 3BD10); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-730 | Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment | Block | Human scFv |
| HPAB-0328CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (HPAB-0328CQ-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| HPAB-0329CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (HPAB-0329CQ-S(P)) | ELISA, FC, FuncS, Agonist | Mouse scFv |
| HPAB-0367LY-S(P) | Human Anti-TSHR Recombinant Antibody (clone 5C9); scfv Fragment | Block, ELISA | Human scfv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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