Anti-cKit-maitansine ADC (LOP628) (CAT#: ADC-L039)
This ADC product is composed of an anti-cKit antibody conjuagated to maitansine (anti-cKit antibody-maitansine). It has demonstrated a response in Inflammatory Diseases treatment by a MOA (Mechanism of Action) of .
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
Figure 2 High expression in breast
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
Figure 3 High expression in lung.
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
Figure 4 Skin
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
Figure 5 RNA cell line category: Group enriched (HEL, HMC-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
Specifications
- Antibody Overview
- Humanized IgG1/κ antibody
- Antibody Conjugation
- Humanized
- Linker
- non-cleavable linker
- Drug
- maitansine
- Drug Class/Description
- Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
Target
- Introduction
- This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- PBT; SCFR; C-Kit; CD117
- Gene ID
- 3815
- UniProt ID
- P10721
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KIT"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibody Products
ADCC Enhanced Antibody Products
ScFv Antibody Products
Human Antibody Products
Mouse Antibody Products
IgG Antibody Products
Chicken IgY Antibody Products
Blocking Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
Fab Antibody Products
IgM Antibody Products
Antibody Magnetic Beads
Cancer Stem Cell Biomarker Specific Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-470CL | Human Anti-KIT Recombinant Antibody (TAB-470CL) | ELISA, WB | Human IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ADC-L039. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, WB, BLI, SPR
Application: ELISA, IP, WB, IHC, IF, FuncS
-1.png)
Application: ELISA, FC, Block, SPR
Application: WB, ELISA, FC, IHC, IP
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: Block, IP, IF, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
