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    • Anti-cKIT (clone 9P3)-SPDB-DM4 ADC (ADC-102CL)
      • Target: cKIT
      • Linker: SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-cKIT (clone 9P3)-CX1-1-DM1 ADC (ADC-103CL)
      • Target: cKIT
      • Linker: CX1-1 (2,5-dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaheptadecan-1-oate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone 9P3)-SMCC-DM1 ADC (ADC-094CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG085)-SMCC-DM1 ADC (ADC-095CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG024)-SMCC-DM1 ADC (ADC-096CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG026)-SMCC-DM1 ADC (ADC-100CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone 20376)-SMCC-DM1 ADC (ADC-097CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG086)-SMCC-DM1 ADC (ADC-098CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG087)-SMCC-DM1 ADC (ADC-099CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-cKIT (clone NEG027)-SMCC-DM1 ADC (ADC-101CL)
      • Target: cKIT
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
    Protein class

    Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (granulocytes, Melanocytes, Inhibitory neurons, Ionocytes, Breast glandular cells)

    Immune cell specificity

    Group enriched (basophil, NK-cell, eosinophil)

    Cell line specificity

    Group enriched (HEL, HMC-1)

    Interaction

    Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts (KITLG/SCF-bound) with IL1RL1. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.

    Molecular function

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

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