Anti-cKIT (clone NEG024)-SMCC-DM1 ADC
CAT#: ADC-096CL
This ADC product is composed of an anti-cKIT antibody (clone NEG024) conjugated via SMCC linker to DM1 (NEG024-MCC-DM1). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
Normal Tissue
Figure 2 High expression in breast
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
Normal Tissue
Figure 3 High expression in lung.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
Normal Tissue
Figure 4 Skin
Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (HEL, HMC-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
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Specifications
- Antibody Overview
- Anti-cKIT Antibody NEG024
- Clone
- NEG024
- Linker
- SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;
- Gene ID
- 3815
- UniProt ID
- A0A024RDA0
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-470CL | Human Anti-KIT Recombinant Antibody (TAB-470CL) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
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| AFC-450CL | Afuco™ Anti-KIT Recombinant Antibody (AFC-450CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-465LC | Human Anti-KIT Recombinant Antibody (TAB-465LC) | ELISA, SPR | Human antibody |
| TAB-466LC | Human Anti-KIT Recombinant Antibody (TAB-466LC) | ELISA, SPR | Human antibody |
| TAB-465LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-465LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-466LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-466LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-468LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-468LC-S(P)) | FC, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0316MZ | Chicken Anti-KIT Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1629CQ | Recombinant Mouse Anti-KIT Antibody (A3C6E2) | FC, BL | IgG1, κ |
| NEUT-1633CQ | Recombinant Rat Anti-Kit Antibody (ACK2) | FC, BL, Depletion | IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1630CQ | Recombinant Mouse Anti-KIT Antibody (CBL788) | WB, FC, CyTOF, ELISA(Cap), Neut | IgG1 |
| NEUT-1631CQ | Recombinant Mouse Anti-KIT Antibody (14G5) | Neut, WB | IgG1 |
| NEUT-1632CQ | Recombinant Mouse Anti-KIT Antibody (12A8) | WB, IP, FC, Neut | IgG1 |
| NEUT-1634CQ | Recombinant Mouse Anti-KIT Antibody (CBL158) | Neut, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1948 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (DS1948AB) | IHC-P, IHC-Fr | IgG |
| MOR-4551 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH61DS) | WB, IF, ICC | IgG |
| MOR-4552 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH62DS) | WB, IF, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-0019-FY-F(E)) | FC | Humanized Fab |
| HPAB-1947-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1947-FY-F(E)) | Block, ELISA, FC, IF | Humanized Fab |
| HPAB-1948-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1948-FY-F(E)) | Block, ELISA, FC, IF | Humanized Fab |
| HPAB-1949-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1949-FY-F(E)) | Block, ELISA, FC, IF | Humanized Fab |
| HPAB-1950-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1950-FY-F(E)) | Block, ELISA, FC, IF | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0156-YC-S(P) | Mouse Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-N0156-YC-S(P)) | ELISA, Inhib, FuncS | Mouse scFv |
| HPAB-N0157-YC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-N0157-YC-S(P)) | ELISA, Inhib, FuncS | Humanized scFv |
| HPAB-1570-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1570-FY-F(E)) | WB, ELISA | Human Fab |
| HPAB-1951-FY-S(P) | Mouse Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1951-FY-S(P)) | Block, ELISA, FC, IF | Mouse scFv |
| HPAB-1952-FY-S(P) | Mouse Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1952-FY-S(P)) | Block, ELISA, FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3398LY | Human Anti-KIT Recombinant Antibody (HPAB-3398LY) | ELISA, FC, WB | Human IgG |
| HPAB-3399LY | Human Anti-KIT Recombinant Antibody (HPAB-3399LY) | ELISA, FC, WB | Human IgG |
| HPAB-1570-FY | Human Anti-KIT Recombinant Antibody (HPAB-1570-FY) | WB, ELISA, Inhib | Human IgG |
| HPAB-1571-FY | Human Anti-KIT Recombinant Antibody (HPAB-1571-FY) | WB, ELISA | Human IgG |
| HPAB-1572-FY | Human Anti-KIT Recombinant Antibody (HPAB-1572-FY) | WB, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX638 | Mouse Anti-KIT Recombinant Antibody (clone 566CT8.5.4) | WB, ICC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1349 | AbPlus™ Anti-Kit Magnetic Beads (VS-0724-YC1349) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC33 | Mouse Anti-KIT Recombinant Antibody (VS-0924-YC33) - Cancer Stem Cell Marker | IHC, WB | |
| VS-0924-YC34 | Rabbit Anti-KIT Antibody (VS-0924-YC34) - Cancer Stem Cell Marker | IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY127 | Mouse Anti-NHP KIT Recombinant Antibody (clone 104D2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY154 | CytoStream™ Mouse Anti-KIT Recombinant Antibody (clone 104D2) | FC | Mouse IgG1 |
| VS-0225-XY155 | CytoStream™ Rat Anti-KIT Recombinant Antibody (clone ACK45) | FC | Rat IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY38 | Human Anti-KIT scFv-Fc Chimera (VS-0325-FY38) | Inhib, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC461 | Recombinant Anti-KIT Vesicular Antibody, EV Displayed (VS-0425-YC461) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3787 | Anti-KIT Immunohistochemistry Kit | IHC | |
| VS-0525-XY3788 | Anti-Mouse KIT Immunohistochemistry Kit | IHC |
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