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    PE-H2-IAd/Human B2M (ACRVNHVTLSQPKIVK) MHC Tetramer (CAT#: MHC-LC2379)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human B2M of peptide ACRVNHVTLSQPKIVK covering 99-114 and H2-IAd molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
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    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, cytosol & the Golgi apparatus.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6361/if_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, cytosol & the Golgi apparatus.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/if_selected.jpg
    Normal Tissue
    Figure 3 Spleen
    Figure 3 Spleen
    (High expression in spleen)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6361/18752_B_7_4_val_selected.jpg
    Figure 4 Bone marrow
    Figure 4 Bone marrow
    (Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_B_6_4.jpg
    Figure 5 Lymph node
    Figure 5 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_A_8_8.jpg
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_B_8_5.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_A_8_5.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166710-B2M

    Specifications

    • Allele
    • H2-IAd
    • Class
    • Class II
    • MHC Species
    • Mouse
    • Antigen
    • B2M
    • Antigen Species
    • Human
    • Peptide
    • ACRVNHVTLSQPKIVK
    • Range
    • 99-114
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
    • Alternative Names
    • B2M; Beta-2-microglobulin precursor; IMD43

    Downloads

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    CAT Product Name Application Type
    MOB-1431z-F(E) Recombinant Anti-Human B2M Antibody Fab Fragment Neut, WB, FuncS Fab
    HPAB-0130-FY-F(E) Human Anti-B2M Recombinant Antibody (clone B2M-1D8); Fab Fragment ELISA Humanized Fab
    HPAB-0131-FY-F(E) Human Anti-B2M Recombinant Antibody (clone B2M-2F6); Fab Fragment ELISA Humanized Fab
    HPAB-0350-FY-F(E) Mouse Anti-B2M Recombinant Antibody (clone FY-007); Fab Fragment ELISA Mouse Fab

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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