Anti-VEGFR2-SPDP-NCS ADC
CAT#: ADC-152LZY
This ADC product is composed of an anti-VEGFR2 antibody conjugated via SPDP linker to NCS (anti-VEGFR2-SPDP-NCS). It has demonstrated a response in Multiple myeloma (MM) treatment by a MOA (Mechanism of Action) of inhibiting DNA synthesis .
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg
Normal Tissue
Figure 2 Placenta
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR
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Specifications
- Antibody Overview
- Anti-VEGFR2 IgG
- Antibody Isotype
- IgG
- Linker
- SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- NCS
- Drug Class/Description
- Class: Neocarzinostatin
Description: Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.
Target
- Introduction
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase);
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
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Datasheet
MSDS
COA
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