This product is a recombinant mouse antibody that can bind to mouse C5 with high affinity.
Figure 1 Immunofluorescence staining of the renal glomerulus from RH-l4-implanted SCID mouse treated with (a) control monoclonalantibody (135.8) (b) anti-C5 (BB5.I) and (c) anti-IL-l0 (BSI0).
There is granular deposition of human IgG in the mesangial areas of SCID mouse treated with control monoclonal antibody and anti-C5. There is a significant reduction (P<0.001) in the immune complex deposition in the anti-IL-10 treated group.
Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., & Isenberg, D. A. (2004). Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody. Rheumatology, 43(4), 442-447.
Figure 2 Pretreatment with anti-C5 moAb significantly reduces early glomerular neutrophil influx.
Glomerulus from a mouse that had received anti-MPO IgG and LPS and was pretreated with anti-C5 moAb, demonstrating strongly reduced neutrophil infiltration.
Huugen, D., Van Esch, A., Xiao, H., Peutz-Kootstra, C. J., Buurman, W. A., Tervaert, J. C.,... & Heeringa, P. (2007). Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney international, 71(7), 646-654.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-901 | Anti-Human C5 Recombinant Antibody (Pexelizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | scFv |
TAB-084CL | Human Anti-C5 Recombinant Antibody (TAB-084CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-1372CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1372CL-S(P)) | Inhib, FuncS | Human scFv |
TAB-1373CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1373CL-S(P)) | IB, Inhib | Humanized scFv |
TAB-1374CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1374CL-S(P)) | ELISA, Inhib | Humanized scFv |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# HPAB-0128CQ, RRID: AB_3111357)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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