Mouse Anti-C5 Recombinant Antibody (clone BB5.1) (CAT#: HPAB-0128CQ)

This product is a recombinant mouse antibody that can bind to mouse C5 with high affinity.

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  • Size:
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  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
IF

Figure 1 Immunofluorescence staining of the renal glomerulus from RH-l4-implanted SCID mouse treated with (a) control monoclonalantibody (135.8) (b) anti-C5 (BB5.I) and (c) anti-IL-l0 (BSI0).

Figure 1 Immunofluorescence staining of the renal glomerulus from RH-l4-implanted SCID mouse treated with (a) control monoclonalantibody (135.8) (b) anti-C5 (BB5.I) and (c) anti-IL-l0 (BSI0).

There is granular deposition of human IgG in the mesangial areas of SCID mouse treated with control monoclonal antibody and anti-C5. There is a significant reduction (P<0.001) in the immune complex deposition in the anti-IL-10 treated group.

Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., & Isenberg, D. A. (2004). Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody. Rheumatology, 43(4), 442-447.

IHC

Figure 2 Pretreatment with anti-C5 moAb significantly reduces early glomerular neutrophil influx.

Figure 2 Pretreatment with anti-C5 moAb significantly reduces early glomerular neutrophil influx.

Glomerulus from a mouse that had received anti-MPO IgG and LPS and was pretreated with anti-C5 moAb, demonstrating strongly reduced neutrophil infiltration.

Huugen, D., Van Esch, A., Xiao, H., Peutz-Kootstra, C. J., Buurman, W. A., Tervaert, J. C.,... & Heeringa, P. (2007). Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney international, 71(7), 646-654.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Mouse C5
  • Species Reactivity
  • Mouse
  • Clone
  • BB5.1
  • Applications
  • FC, IA, IF, IP, IHC, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Immunofluorescence and Immunohistochemistry. Please see the Published Data for further information.

Target

  • Alternative Names
  • C5D; C5a; C5b; ECLZB; CPAMD4

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# HPAB-0128CQ, RRID: AB_3111357)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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