Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced
CAT#: VS-0924-YC112
The product is a hexameric mouse anti-CD37 antibody with enhanced complement-dependent cytotoxicity (CDC) activity. This IgG1 antibody targeting human CD37 has been engineered with hexamerization-enhancing mutations to promote hexamer formation, facilitating optimal C1q binding and augmenting CDC efficacy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human CD37
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, Inhib, CDC
- Conjugate
- None
- Related Disease
- Type 1 Diabetes, Agents for; Multiple Sclerosis, Agents for; Rheumatoid Arthritis
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40
- Gene ID
- 951
- UniProt ID
- P11049
- Long Name
- CD37 Molecule
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Tyrosine phosphorylated; leading to activation of downstream signaling pathways. ( P11049-CD37_HUMAN )
Glycosylation at Asn170, Asn183, and Asn188 ( NX_P11049 [NX_P11049-1] )
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
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| HPAB-1046-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1046-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-1047-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1047-FY-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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