Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced (CAT#: VS-0924-YC112)
The product is a hexameric mouse anti-CD37 antibody with enhanced complement-dependent cytotoxicity (CDC) activity. This IgG1 antibody targeting human CD37 has been engineered with hexamerization-enhancing mutations to promote hexamer formation, facilitating optimal C1q binding and augmenting CDC efficacy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Figure 5 Spleen
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human CD37
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, Inhib, CDC
- Conjugate
- None
- Related Disease
- Type 1 Diabetes, Agents for; Multiple Sclerosis, Agents for; Rheumatoid Arthritis
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40
- Gene ID
- 951
- UniProt ID
- P11049
- Long Name
- CD37 Molecule
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Tyrosine phosphorylated; leading to activation of downstream signaling pathways. ( P11049-CD37_HUMAN )
Glycosylation at Asn170, Asn183, and Asn188 ( NX_P11049 [NX_P11049-1] )
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD37"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibody Products
Chimeric Antibody Products
Mouse Antibody Products
ADCC Enhanced Antibody Products
ScFv Antibody Products
Fab Antibody Products
IgG Antibody Products
Hexamer Antibody Products
ScFv-Fc Chimera Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0924-YC112. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, WB, BLI, SPR
Application: ELISA, Neut, FuncS
-CB2006C17L-4.jpg)
Application: WB, ELISA
Application: WB, ELISA, Neut, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
