Anti-Human CD37 Recombinant Antibody (Otlertuzumab)
CAT#: TAB-904
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD37. Otlertuzumab is a humanized monoclonal antibody designed for the treatment of cancer
Published Data
Gene Expression
Figure 1 Serum concentrations of otlertuzumab were measured at multiple time points throughout the dosing cycle and mean concentrations over time are plotted for all 3 NHL treatment groups.
Mean otlertuzumab concentrations versus nominal time. Concentrations were similar between non-Hodgkin lymphoma (NHL) types.
(2015). Otlertuzumab (tru‐016), an anti‐cd37 monospecific adaptir™ therapeutic protein, for relapsed or refractory nhl patients. British Journal of Haematology, 168(1), 38-45.
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Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- VH - V-kappa - CH2 - CH3
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF, ICC
- CAS
- 1372645-37-8
- Generic Name
- Otlertuzumab
- MW
- 107.5 kDa
- Related Disease
- Chronic lymphocytic leukemia (CLL)
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- The CD37 antibody has been reported in applications of PK.
Target
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(Creative Biolabs Cat# TAB-904, RRID: AB_3112020)
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Biosimilar Overview
Please refer to Otlertuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Otlertuzumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CD37"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Human Anti-CD37 Recombinant Antibody (TAB-0272CL) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0273CL-S(P)) | Block | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
| HPAB-0901-WJ-F(E) | Mouse Anti-CD37 Recombinant Antibody Fab Fragment (HPAB-0901-WJ-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP033-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment | FuncS | Human scFv |
| HPAB-AP034-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone B2); scFv Fragment | FuncS | Human scFv |
| HPAB-1045-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1045-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1046-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1046-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1047-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1047-FY-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1051CQ | Human Anti-CD37 Recombinant Antibody (clone G28-1) | Depletion | Human IgG1 |
| FAMAB-1052CQ | Mouse Anti-CD37 Recombinant Antibody (clone WR17) | FC | Mouse IgG2a |
| FAMAB-1053CQ | Human Anti-CD37 Recombinant Antibody (clone MB-1) | ICC, IHC-P, WB, FC | Human IgG1 |
| ZG-0384F | Mouse Anti-CD37 Recombinant Antibody (ZG-0384F) | IF, ELISA | Mouse IgG |
| VS3-XY281 | Mouse Anti-CD37 Recombinant Antibody (clone 2B8) | ELISA, WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC9 | Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
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