Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab
CAT#: VS-0525-YC9
This product is engineered to bind two distinct epitopes on the tumor-associated antigen CD37. It incorporates an E430G mutation to enhance hexamer formation (six antibody molecules joined) on the cell surface, which triggers complement-dependent cytotoxicity (CDC) and also prompts antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis (ADCP).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human CD37
- Species Reactivity
- Human
- Type
- Asymmetric hetero Fab
- Valency
- 1 + 1
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- CD37 Molecule
Target
- Introduction
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions.
- Alternative Names
- GP52-40; TSPAN26
- Gene ID
- 9512
- UniProt ID
- P11049
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0273CL-F(E)) | Block | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) | Activ, Depletion, FuncS, Inhib | Mouse scFv |
| HPAB-0163-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0163-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-0164-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0164-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-1045-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1045-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1046-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1046-FY-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-1045-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1045-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-1046-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1046-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-1047-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1047-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-0901-WJ-F(E) | Mouse Anti-CD37 Recombinant Antibody Fab Fragment (HPAB-0901-WJ-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
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