Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab (CAT#: VS-0525-YC9)

This product is engineered to bind two distinct epitopes on the tumor-associated antigen CD37. It incorporates an E430G mutation to enhance hexamer formation (six antibody molecules joined) on the cell surface, which triggers complement-dependent cytotoxicity (CDC) and also prompts antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis (ADCP).

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Animal 1
  • Human
  • Host Animal 2
  • Human
  • Specificity
  • Human CD37
  • Species Reactivity
  • Human
  • Type
  • Asymmetric hetero Fab
  • Valency
  • 1 + 1
  • Purity
  • >90%
  • Purification
  • Affinity purified
  • Applications
  • ELISA
  • Concentration
  • Lot specific
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
  • Long Name
  • CD37 Molecule

Target

  • Introduction
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions.
  • Alternative Names
  • GP52-40; TSPAN26

Downloads

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See other products for "CD37"

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Humanized Antibodies Chimeric Antibodies Mouse Antibodies IgG Antibodies ScFv Antibodies Fab Antibodies ADCC Enhanced Antibodies Hexamer Antibodies ScFv-Fc Chimeras FC Reagents & Kits Extracellular Vesicle Antibodies
CAT Product Name Application Type
TAB-904 Anti-Human CD37 Recombinant Antibody (Otlertuzumab) ELISA, IP, FC, FuncS, Neut, IF, ICC VH - V-kappa - CH2 - CH3

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