Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera (CAT#: VS-0125-FY21)
This is a single-chain antibody-Fc (scFv-Fc) complex targeting human CD37, which can specifically target B cells. This antibody offers new possibilities for the treatment of patients with B-cell lymphoid malignancies, demonstrating good targeting ability and potential efficacy. By targeting CD37, this antibody is expected to effectively inhibit the growth of tumor cells and improve patient prognosis. Researchers are further evaluating its safety and efficacy in clinical applications, with the aim of providing patients with more treatment options.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Figure 5 Spleen
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- chHH1.1
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-CD37 scFv-FC aims to provide new treatment options for patients with B cell-related malignancies.
Target
- Alternative Names
- CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40
- Gene ID
- 951
- UniProt ID
- P11049
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Tyrosine phosphorylated; leading to activation of downstream signaling pathways.
Glycosylation at Asn170, Asn183, and Asn188
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_005259492.1; XP_011525844.1; XP_011525845.1; XP_054178685.1; XP_054178686.1
- Function
- Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.
Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking.
Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1367z | Mouse Anti-CD37 Recombinant Antibody (clone 41C4) | WB, IP, IF, IHC, ELISA | Mouse IgG2b, κ |
| HPAB-1045-FY | Human Anti-CD37 Recombinant Antibody (HPAB-1045-FY) | FC, ELISA | Humanized IgG |
| HPAB-1046-FY | Human Anti-CD37 Recombinant Antibody (HPAB-1046-FY) | FC, ELISA | Humanized IgG |
| HPAB-1047-FY | Human Anti-CD37 Recombinant Antibody (HPAB-1047-FY) | ELISA, FC, IHC | Humanized IgG |
| VS-0723-WK47 | Human Anti-CD37 Recombinant Antibody (clone Naratuximab) | FC | Chimeric (mouse/human) IgG1 |
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