Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera
CAT#: VS-0125-FY21
This is a single-chain antibody-Fc (scFv-Fc) complex targeting human CD37, which can specifically target B cells. This antibody offers new possibilities for the treatment of patients with B-cell lymphoid malignancies, demonstrating good targeting ability and potential efficacy. By targeting CD37, this antibody is expected to effectively inhibit the growth of tumor cells and improve patient prognosis. Researchers are further evaluating its safety and efficacy in clinical applications, with the aim of providing patients with more treatment options.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- chHH1.1
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-CD37 scFv-FC aims to provide new treatment options for patients with B cell-related malignancies.
Target
- Alternative Names
- CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40
- Gene ID
- 951
- UniProt ID
- P11049
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Tyrosine phosphorylated; leading to activation of downstream signaling pathways.
Glycosylation at Asn170, Asn183, and Asn188
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_005259492.1; XP_011525844.1; XP_011525845.1; XP_054178685.1; XP_054178686.1
- Function
- Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.
Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking.
Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone chHH1.1"
- CAT
- Product Name
See other products for "CD37"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1367z | Mouse Anti-CD37 Recombinant Antibody (clone 41C4) | WB, IP, IF, IHC, ELISA | Mouse IgG2b, κ |
| FAMAB-1051CQ | Human Anti-CD37 Recombinant Antibody (clone G28-1) | Depletion | Human IgG1 |
| FAMAB-1052CQ | Mouse Anti-CD37 Recombinant Antibody (clone WR17) | FC | Mouse IgG2a |
| FAMAB-1053CQ | Human Anti-CD37 Recombinant Antibody (clone MB-1) | ICC, IHC-P, WB, FC | Human IgG1 |
| VS3-XY281 | Mouse Anti-CD37 Recombinant Antibody (clone 2B8) | ELISA, WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Human Anti-CD37 Recombinant Antibody (TAB-0272CL) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0273CL-S(P)) | Block | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) | Activ, Depletion, FuncS, Inhib | Mouse scFv |
| HPAB-1045-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1045-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1046-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1046-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1047-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1047-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-0901-WJ-S(P) | Mouse Anti-CD37 Recombinant Antibody scFv Fragment (HPAB-0901-WJ-S(P)) | FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
| HPAB-0901-WJ-F(E) | Mouse Anti-CD37 Recombinant Antibody Fab Fragment (HPAB-0901-WJ-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC9 | Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
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