Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0273CL-S(P)) (CAT#: TAB-0273CL-S(P))
The chimeric anti-CD37 antibody originates from a murine monoclonal antibody. The antibody did have a noticeable impact on targeted cell death in Daudi cells through the ADCC mechanism. TAB-0273CL-S(P) antibody is the scfv fragment antibody form of TAB-0273CL antibody. Single-chain variable fragments (scFvs) are artificial constructs consisting of the variable regions of the immunoglobulin heavy and light chains connected by a peptide linker.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Figure 5 Spleen
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
Specifications
- Host Species
- Human
- Type
- Chimeric (mouse/human)
- Specificity
- Human
- Related Disease
- Hematologic cancer, B cell malignancies, autoimmune conditions
Applications
- Application Notes
- Block assay: 20 μg/mL
Target
- Alternative Names
- CD37; CD37 molecule; GP52-40; TSPAN26; leukocyte antigen CD37; tspan-26; tetraspanin-26; leukocyte surface antigen CD37; cell differentiation antigen 37;
- Gene ID
- 951
- UniProt ID
- P11049
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
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