Mouse Anti-CEACAM5 Recombinant Antibody (clone CB30) (CAT#: VS3-CJ447)
This product is a mouse antibody that recognizes human CEACAM5 (CD66e).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
Figure 3 Colon
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
Figure 4 Rectum
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human CEACAM5 (CD66e)
- Species Reactivity
- Human
- Clone
- CB30
- Applications
- IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS, pH 7.3.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for one year. Do not freeze.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Immunofluorescence, Flow Cytometry.
Target
- Alternative Names
- CEA; CD66e
- Gene ID
- 1048
- UniProt ID
- P06731
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. CEA family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
- Protein Refseq
- NP_001278413.1; NP_001295327.1; NP_004354.3
- Function
- Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CEACAM5"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703 | Anti-Human CEACAM5 Recombinant Antibody (Altumomab) | IF, IP, Neut, FuncS, ELISA, FC, IHC | IgG1 |
| TAB-418LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 9) | FC, WB | |
| TAB-419LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 12) | FC, WB | |
| TAB-420LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 13) | FC, WB | |
| TAB-421LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 15) | FC, WB |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L003E | anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L003R | anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L004E | anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L004R | anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA | Cytotoxicity assay, Functional assay |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-409LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-409LC) | SPR, ELISA, FC | Humanized antibody |
| TAB-412LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-412LC) | ELISA, FC | Chimeric (Mouse/Human) IgG1 |
| TAB-409LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P)) | SPR, ELISA, FC | Humanized scFv |
| TAB-412LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P)) | FC, ELISA | Human scFv |
| TAB-413LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-413LC-S(P)) | FC, ELISA | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-410LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-410LC) | ELISA | Humanized antibody |
| TAB-414LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-414LC) | ELISA, FC, Inhib | Human IgG1 |
| TAB-415LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-415LC) | ELISA, FC, Inhib | Human IgG1 |
| TAB-416LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-416LC) | ELISA, FC, Inhib | Human IgG1 |
| TAB-410LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E)) | ELISA | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-411LC-S(P) | Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment | ELISA | Human antibody |
| TAB-411LC-F(E) | Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment | ELISA | Human antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002LC-VHH | Anti-Human CEACAM5 Recombinant Antibody(VHH library) | SPR, FC, ELISA | Single domain antibody |
| HPAB-0204-FY | Recombinant llama Anti-CEACAM5 Antibody (11C12) | ADCC, ELISA | llama VHH |
| HPAB-0205-FY | Recombinant llama Anti-CEACAM5 Antibody (15E7) | ADCC, E | llama VHH |
| HPAB-0206-FY | Recombinant llama Anti-CEACAM5 Antibody (2C2) | ADCC, E | llama VHH |
| HPAB-1024WJ | Recombinant Camelid Anti-CEACAM5 Single Domain Antibody | SPR, Inhib | Camelid VHH |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0118MZ | Chicken Anti-CEACAM5 Polyclonal IgY | WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0649 | Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) | IHC | Rabbit IgG |
MHC Tetramer for Cancer
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY | Mouse Anti-CEACAM5 Recombinant Antibody (HPAB-0155-FY) | Activ, FuncS | Humanized IgG1, κ |
| HPAB-0243-FY | Human Anti-CEACAM5 Recombinant Antibody (clone M5A) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| HPAB-0348-YJ | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1) | ELISA, IHC | Mouse IgG1 |
| FAMAB-1027CQ | Human Anti-CEACAM5 Recombinant Antibody (clone EB-022) | ELISA | Human IgG1 |
| FAMAB-1028CQ | Human Anti-CEACAM5 Recombinant Antibody (clone EB-011) | ELISA | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) | Activ | Humanized scFv |
| HPAB-0243-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody (clone M5A); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0348-YJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1094WJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-1094WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2106-FY-S(P) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); scFv Fragment | ELISA, FC, Inhib | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) | Activ | Humanized Fab |
| HPAB-0243-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody (clone M5A); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
| HPAB-0348-YJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1094WJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2106-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment | ELISA, FC, Inhib | Human Fab, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-703 | Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody (Altumomab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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