Anti-CTLA4 (clone 4.8.1) Recombinant Antibody Coupled Liposome (VS-1024-FY273) (CAT#: VS-1024-FY273)
Anti-CTLA-4 antibody conjugated liposomes hold significant potential in the treatment of metastatic fibrosarcoma by enhancing immune activation against tumor cells. These liposomes can effectively deliver targeted immunotherapy, improving the specific binding of the antibody to immune checkpoint molecules, thereby blocking inhibitory signals that dampen the immune response. Additionally, the liposomal formulation allows for sustained release of the antibody, potentially increasing therapeutic efficacy while minimizing systemic side effects. As a novel delivery system, this approach could pave the way for improved outcomes in metastatic fibrosarcoma management and may serve as a model for other cancers utilizing immunomodulatory therapies.
More Infomation
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Specifications
- Potential Clinical Applications
- Metastatic fbrosarcoma
Product Composition
- Clone
- 4.8.1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was meticulously engineered to specifically target and inhibit CTLA-4, a protein that plays a crucial role in downregulating the immune response. By binding to CTLA-4, this antibody effectively enhances T-cell activation and proliferation, ultimately promoting a more robust immune response against cancer cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CTLA4
- Alternative Names
- Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4
- Full Name
- Cytotoxic T-Lymphocyte Associated Protein 4
- Gene ID
- 1493
- UniProt ID
- P16410
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation is important for dimerization. (P16410-CTLA4_HUMAN)
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. (P16410-CTLA4_HUMAN)
Glycosylation at Asn113 and Asn145 (NX_P16410 [NX_P16410-1])
Modification sites at PhosphoSitePlus (P16410)
Glycosylation from GlyGen (P16410) 2 sites
- Protein Refseq
- NP_001032720.1
- Function
- Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Recommended Products
Related Resources
Rheumatoid Arthritis
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 4.8.1"
See other products for "CTLA4"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products
Immunotoxin Products
Rat Antibody Products
Chimeric Antibody Products
Humanized Antibody Products
Mouse Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
ADCC Enhanced Antibody Products
Single Domain Antibody Products
Agonistic Antibody Products
Antibody Magnetic Beads
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067 | Anti-Human CTLA4 Recombinant Antibody (TAB-067) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-1024-FY273. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, WB, BLI, SPR
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: ELISA, FC, Inhib, FuncS
Application: ELISA, IHC, IF, IP
Application: ELISA, Neut, FuncS
Application: ELISA, Inhib, FuncS
Application: WB, IHC-Fr, IHC-P, ICC, IF
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
