Anti-CTLA4 (clone 4.8.1) Recombinant Antibody Coupled Liposome (VS-1024-FY273)
CAT#: VS-1024-FY273
Anti-CTLA-4 antibody conjugated liposomes hold significant potential in the treatment of metastatic fibrosarcoma by enhancing immune activation against tumor cells. These liposomes can effectively deliver targeted immunotherapy, improving the specific binding of the antibody to immune checkpoint molecules, thereby blocking inhibitory signals that dampen the immune response. Additionally, the liposomal formulation allows for sustained release of the antibody, potentially increasing therapeutic efficacy while minimizing systemic side effects. As a novel delivery system, this approach could pave the way for improved outcomes in metastatic fibrosarcoma management and may serve as a model for other cancers utilizing immunomodulatory therapies.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
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More Infomation
Specifications
- Potential Clinical Applications
- Metastatic fbrosarcoma
Product Composition
- Clone
- 4.8.1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was meticulously engineered to specifically target and inhibit CTLA-4, a protein that plays a crucial role in downregulating the immune response. By binding to CTLA-4, this antibody effectively enhances T-cell activation and proliferation, ultimately promoting a more robust immune response against cancer cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CTLA4
- Alternative Names
- Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4
- Full Name
- Cytotoxic T-Lymphocyte Associated Protein 4
- Gene ID
- 1493
- UniProt ID
- P16410
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation is important for dimerization. (P16410-CTLA4_HUMAN)
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. (P16410-CTLA4_HUMAN)
Glycosylation at Asn113 and Asn145 (NX_P16410 [NX_P16410-1])
Modification sites at PhosphoSitePlus (P16410)
Glycosylation from GlyGen (P16410) 2 sites
- Protein Refseq
- NP_001032720.1
- Function
- Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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Related Diseases
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-986 | Recombinant Mouse Anti-Human CTLA4 Antibody F(ab')2 Fragment, clone ANC152.2/8H5 | FC, EIA, FX, Bios | F(ab')2 |
| DrMAB-987 | Mouse Anti-CTLA4 Recombinant Antibody (clone ANC152.2/8H5); Fab Fragment | FC, ELISA | Mouse Fab |
| HPAB-0157-FY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0157-FY-F(E)) | Activ | Humanized Fab |
| HPAB-0749LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0750LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) | FuncS, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067 | Anti-Human CTLA4 Recombinant Antibody (TAB-067) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G015E | Anti-CTLA4 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G015S | Anti-CTLA4 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G015M | Anti-CTLA4 immunotoxin (scFv)-Mel | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195CL | Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-083MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2122.H) | ELISA, FC | Humanized antibody |
| TAB-084MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2422.H) | ELISA, FC | Humanized antibody |
| TAB-088MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-088MZ) | ELISA | Human IgG |
| TAB-091MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-091MZ) | ELISA | Human IgG1 |
| TAB-092MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-092MZ) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-085MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-086MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-085MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-086MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-085MZ-F(E) | Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-087MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-087MZ) | ELISA | Mouse IgG |
| TAB-089MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-089MZ) | ELISA | Mouse IgG1 |
| TAB-090MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-090MZ) | ELISA | Mouse IgG1 |
| TAB-093MZ | Anti-Human CTLA4 Recombinant Antibody (Mu-26B) | ELISA | |
| TAB-087MZ-S(P) | Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-567CQ | Mouse Anti-CTLA4 Recombinant Antibody (NEUT-567CQ) | FC, FuncS, Neut, IP, WB | Mouse IgG2a, κ |
| NEUT-569CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) | WB, Neut | Mouse IgG1 |
| NEUT-570CQ | Human Anti-CTLA4 Recombinant Antibody (clone YC030) | Neut | Human IgG1, κ |
| NEUT-572CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9) | FC, Block, ELISA, IP | Hamster IgG |
| NEUT-573CQ | Rat Anti-Ctla4 Recombinant Antibody (clone 63828) | WB, FC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-568CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) | FC, Block | Mouse IgG1, κ |
| NEUT-571CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) | Block, FC | Mouse IgG2a |
| NEUT-577CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835) | Block, FC | Hamster IgG |
| NEUT-578CQ | Hamster Anti-Ctla4 Recombinant Antibody (NEUT-578CQ) | Block | Hamster IgG |
| NEUT-579CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone 9H10) | FC, Block | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0855 | Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0157-FY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0157-FY) | Activ | Humanized IgG1, κ |
| HPAB-0749LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0749LY) | FuncS, ELISA | Human IgG |
| HPAB-0750LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0750LY) | FuncS, ELISA | Human IgG |
| HPAB-0751LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0751LY) | FuncS, ELISA | Human IgG |
| HPAB-0752LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0752LY) | FuncS, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-610-FY-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-610-FY-S(P)) | ELISA | Human scFv |
| HPAB-611-FY-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-611-FY-S(P)) | ELISA | Human scFv |
| HPAB-N0054-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody scFv Fragment (HPAB-N0054-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-N0055-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody scFv Fragment (HPAB-N0055-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-N0056-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-N0056-YC-S(P)) | ELISA, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-067 | Afuco™ Anti-CTLA4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-067) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-206 | Afuco™ Anti-CTLA4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-206) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP863-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC) | ELISA, Block | Camel VHH |
| HPAB-AP864-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC) | ELISA, Block | Camel VHH |
| HPAB-AP865-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP865-YC) | ELISA, Block | Camel VHH |
| HPAB-AP866-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP866-YC) | ELISA, Block | Camel VHH |
| HPAB-AP867-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP867-YC) | ELISA, Block | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY22 | Mouse Anti-CTLA4 Agonistic Antibody (VS-0724-XY22) | WB, Agonistic assays | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY73 | AbPlus™ Anti-CTLA4 Magnetic Beads (14D3) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY92 | CytoStream™ Mouse Anti-CTLA4 Recombinant Antibody (clone BNI3) | FC | Mouse IgG2a, kappa |
| VS-0225-XY93 | CytoStream™ Armenian Hamster Anti-CTLA4 Recombinant Antibody (clone UC10-4F10-11) | FC, IP | Armenian Hamster IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY63 | Human Anti-CTLA4 (clone JMW-3B3) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC558 | Recombinant Anti-CTLA4 Vesicular Antibody, EV Displayed (VS-0425-YC558) | ELISA, FC, SPR, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1763 | Anti-CTLA4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1764 | Anti-Mouse CTLA4 Immunohistochemistry Kit | IHC |
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