Mouse Anti-CTLA4 Recombinant Antibody (VS3-FY2678)

Name: Mouse Anti-CTLA4 Recombinant Antibody (VS3-FY2678)
SKU: VS3-FY2678
Rating: 5 (1 reviews)

CAT#: VS3-FY2678

The anti-CTLA4 antibody is a mouse IgG1 recombinant monoclonal antibody that demonstrated capability to bind to human CTLA4. The antibody can be used in detection of CTLA4 by ELISA, Western Blot assays. This monoclonal antibody is potential for conducting research on research of celiac disease 3.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4

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Specifications

Host Species
Mouse

Type
Mouse IgG

Specificity
Cytotoxic T-lymphocyte associated protein 4 of human

Species Reactivity
Human

Applications
ELISA, WB

Conjugate
Unconjugated, FITC

Related Disease
Celiac Disease 3

Product Property

Clonality
Monoclonal Antibody

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
ELISA: 1/20000
Western Blot: 1/500-2000

Target

Alternative Names
Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4

Gene ID
1493

UniProt ID
P16410

Cellular Localization
Cell membrane

Post Translation Modifications
N-glycosylation is important for dimerization.
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Glycosylation at Asn113 and Asn145
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites

Protein Refseq
NP_001032720.1

Function
Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

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Related Diseases

Rheumatoid Arthritis

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-FY2678.pdf

MSDS

MSDS - VS3-FY2678.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Secondary Antibody

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