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    Mouse Anti-CTLA4 Recombinant Antibody (VS3-FY2678)

    CAT#: VS3-FY2678

    The anti-CTLA4 antibody is a mouse IgG1 recombinant monoclonal antibody that demonstrated capability to bind to human CTLA4. The antibody can be used in detection of CTLA4 by ELISA, Western Blot assays. This monoclonal antibody is potential for conducting research on research of celiac disease 3.

    Gene Expression
    ❮
    Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
    ❯

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Cytotoxic T-lymphocyte associated protein 4 of human
    • Species Reactivity
    • Human
    • Applications
    • ELISA, WB
    • Conjugate
    • Unconjugated, FITC
    • Related Disease
    • Celiac Disease 3

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • ELISA: 1/20000
      Western Blot: 1/500-2000

    Target

    • Alternative Names
    • Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • N-glycosylation is important for dimerization.
      Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
      Glycosylation at Asn113 and Asn145
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 2 sites
    • Function
    • Inhibitory receptor acting as a major negative regulator of T-cell responses.
      The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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    Related Diseases

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    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS3-FY2678.pdf

    MSDS

    MSDS - VS3-FY2678.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Secondary Antibody

    • CAT
    • Product Name

    Isotype Control

    • CAT
    • Product Name

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