Anti-DKK1 (clone BHQ880) Recombinant Antibody Coupled Liposome (VS-1024-FY145)
CAT#: VS-1024-FY145
Liposomes conjugated with anti-DKK1 antibodies show promising therapeutic potential in colorectal cancer research, as DKK1 is closely associated with tumor progression in various cancers. This conjugation targets and inhibits DKK1, thereby altering the tumor microenvironment and suppressing tumor growth. The use of liposomes aids in enhancing the bioavailability and therapeutic effects of drugs. This method provides new ideas for innovative treatment strategies in colorectal cancer.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- BHQ880
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically engineered to target DKK1, a protein that plays a crucial role in various cellular processes. By binding to DKK1, this antibody aims to modulate the signaling pathways associated with this protein, potentially offering new therapeutic avenues for conditions where DKK1 is implicated. The design of this monoclonal antibody incorporates advanced biotechnological techniques to enhance its specificity and effectiveness, ensuring that it precisely interacts with DKK1 without affecting other proteins. As research progresses, this antibody could pave the way for innovative treatments in diseases such as cancer and osteoporosis, where DKK1 is known to be a significant factor.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- DKK1
- Introduction
- This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
- Alternative Names
- DKK-1; SK
- Full Name
- Dickkopf WNT Signaling Pathway Inhibitor 1
- Gene ID
- 22943
- UniProt ID
- O94907
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Ser61, Thr155, Ser163, Thr164, Ser169, Thr172, Thr173, Thr181, and Asn256 (NX_O94907 [NX_O94907-1])
Modification sites at PhosphoSitePlus (O94907)
Glycosylation from GlyGen (O94907) 18 sites, 1 O-linked glycan (13 sites)
- Protein Refseq
- NP_036374.1
- Function
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-196MZ | Rat Anti-DKK1 Recombinant Antibody (TAB-196MZ) | FuncS | Rat IgG |
| TAB-192MZ-F(E) | Anti-Mouse DKK1 Recombinant Antibody Fab Fragment (JC18) | ELISA | |
| TAB-194MZ-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-194MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195MZ | Human Anti-DKK1 Recombinant Antibody (TAB-195MZ) | In vivo efficacy assay | Human IgG |
| TAB-197MZ | Anti-Human DKK1 Recombinant Antibody (RH1-10) | Inhib | Human antibody |
| TAB-198MZ | Anti-Human DKK1 Recombinant Antibody (RH2-18) | ELISA, FuncS, Inhib | Human antibody |
| TAB-199MZ | Anti-Human DKK1 Recombinant Antibody (RH2-31) | Inhib | Human antibody |
| TAB-200MZ | Anti-Human DKK1 Recombinant Antibody (RH2-59) | Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
| TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) | ELISA | Single domain antibody |
| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
| TAB-013MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-013MZ-VHH) | ELISA | Single domain antibody |
| HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| MOR-4137 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0278-YC) | ELISA, Block, FuncS | Human IgG |
| HPAB-0279-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) | Block, FuncS | Human IgG |
| HPAB-0280-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0280-YC) | ELISA | Human IgG |
| HPAB-670-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) | ELISA | Human IgG, λ |
| ZG-0479F | Mouse Anti-DKK1 Recombinant Antibody (ZG-0479F) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0278-YC-F(E)) | ELISA, Block, FuncS | Human Fab |
| HPAB-0279-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0279-YC-F(E)) | Block, FuncS | Human Fab |
| HPAB-0280-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0280-YC-F(E)) | ELISA | Human Fab |
| HPAB-0096-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) | FuncS | Human Fab |
| HPAB-670-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-670-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0757-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0757-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0758-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0758-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0759-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0759-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0760-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0760-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0761-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0761-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2001 | Anti-DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2002 | Anti-Mouse DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2003 | Anti-Human DKK1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC46 | Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80) | Inhib | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC89 | Recombinant Anti-DKK1 Eliminating Antibody, pH-Sensitive (VS-0625-YC89) | Antigen-Sweeping In Vivo. | Human IgG |
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