Anti-DKK1 (clone BHQ880) Recombinant Antibody Coupled Liposome (VS-1024-FY145) (CAT#: VS-1024-FY145)

• Potential Clinical Applications
• Colorectal cancer

• Clone
• BHQ880

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that was specifically engineered to target DKK1, a protein that plays a crucial role in various cellular processes. By binding to DKK1, this antibody aims to modulate the signaling pathways associated with this protein, potentially offering new therapeutic avenues for conditions where DKK1 is implicated. The design of this monoclonal antibody incorporates advanced biotechnological techniques to enhance its specificity and effectiveness, ensuring that it precisely interacts with DKK1 without affecting other proteins. As research progresses, this antibody could pave the way for innovative treatments in diseases such as cancer and osteoporosis, where DKK1 is known to be a significant factor.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• DKK1

• Introduction
• This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.

• Alternative Names
• DKK-1; SK

• Full Name
• Dickkopf WNT Signaling Pathway Inhibitor 1

• Gene ID
• 22943

• UniProt ID
• O94907

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Ser61, Thr155, Ser163, Thr164, Ser169, Thr172, Thr173, Thr181, and Asn256 (NX_O94907 [NX_O94907-1])
  Modification sites at PhosphoSitePlus (O94907)
  Glycosylation from GlyGen (O94907) 18 sites, 1 O-linked glycan (13 sites)

• Protein Refseq
• NP_036374.1

• Function
• Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.

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