Anti-FAP Antibody-Cytokine Fusion Protein, IgG (Sibrotuzumab)-hIL13 (CAT#: VS-0624-FY94)

• Target
• FAP

• Molecule Class
• IgG-IL13

• Species Reactivity
• Human

• Clone
• Sibrotuzumab

• Related Disease
• Cancer

• Cytokine 1
• IL13

• Cytokines 1 Description
• The effects of IL-13 on immune cells are similar to those of the closely related cytokine IL-4. However, IL-13 is suspected to be a central mediator of the physiological changes induced by allergic inflammation in many tissues.

• Cytokine 1 Species
• Human

• Applications
• This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Alternative Names
• Fibroblast Activation Protein Alpha; Seprase; 170 KDa Melanoma Membrane-Bound Gelatinase; Gelatine Degradation Protease FAP; Integral Membrane Serine Protease; Post-Proline Cleaving Enzyme; Surface-Expressed Protease; Dipeptidyl Peptidase FAP; FAPalpha; SIMP

• Gene ID
• 2191

• UniProt ID
• Q12884

• VS-0624-FY92
• Anti-FAP Antibody-Cytokine Fusion Protein, scfv (Sibrotuzumab)-mIL12

• VS-0624-FY93
• Anti-FAP Antibody-Cytokine Fusion Protein, scfv (Sibrotuzumab)-hIL12

• VS-0624-FY95
• Anti-FAP Antibody-Cytokine Fusion Protein, IgG (Sibrotuzumab)-mIL13

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