Anti-FAP Antibody-Cytokine Fusion Protein, scfv (Sibrotuzumab)-hIL12
CAT#: VS-0624-FY93
Sibrotuzumab is a humanized monoclonal antibody that binds to fibroblast activation protein α (FAPα), an inducible tumor stromal antigen. IL-12 is a cytokine that is naturally produced by cells in the innate immune system. IL-12 affects immune responses in many ways, so it is closely related to immune-mediated diseases. The product is a human recombinant anti-human FAP-IL12 fusion protein. This is a novel FAP-specific immunocytokine, which is generated by fusing human IL-12 to the N-terminus of Sibrotuzumab in a tandem diabody format.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_9_3.jpg
Normal Tissue
Figure 2 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_8_4.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_4_6.jpg
Normal Tissue
Figure 5 Smooth muscle
Smooth muscle cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_B_6_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, hTERT-RPE1, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000078098-FAP
❮
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Specifications
- Target
- FAP
- Molecule Class
- scfv-IL12
- Species Reactivity
- Human
- Clone
- Sibrotuzumab
- Related Disease
- Cancer
- Cytokine 1
- IL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells, and human B lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the interleukin 12 family. The IL-12 family is unique in that it contains only heterodimeric cytokines, including IL-12, IL-23, IL-27, and IL-35. Although they share many common structural features and molecular partners, the functional effects they mediate are surprisingly diverse.
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- Fibroblast Activation Protein Alpha; Seprase; 170 KDa Melanoma Membrane-Bound Gelatinase; Gelatine Degradation Protease FAP; Integral Membrane Serine Protease; Post-Proline Cleaving Enzyme; Surface-Expressed Protease; Dipeptidyl Peptidase FAP; FAPalpha; SIMP
- Gene ID
- 2191
- UniProt ID
- Q12884
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Datasheet
MSDS
COA
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See other products for "Clone Sibrotuzumab"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-211 | Anti-Human FAP Recombinant Antibody (TAB-211) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022WM | Human Anti-FAP Recombinant Antibody (TAB-022WM) | FC, ELISA | Human IgG1 |
| TAB-022WM-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (TAB-022WM-S(P)) | FC, ELISA | Human scFv |
| TAB-024WM-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (TAB-024WM-S(P)) | ELISA, FC, IF | Human scFv |
| TAB-022WM-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (TAB-022WM-F(E)) | FC, ELISA | Human Fab |
| TAB-024WM-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (TAB-024WM-F(E)) | ELISA, FC, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-150LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-151LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-152LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-153LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-153LC | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0172-CN | Human Anti-FAP Recombinant Antibody (HPAB-0172-CN) | ELISA, IHC | Chimeric (mouse/human) IgG1, κ |
| HPAB-0176-CN | Human Anti-FAP Recombinant Antibody (clone cF19) | ELISA, FC, IHC, IP, IF | Chimeric (mouse/human) IgG1 |
| MRO-0568-CN | Rabbit Anti-FAP Recombinant Antibody (clone JA56-11) | WB, IHC | Rabbit IgG |
| MRO-1853-CN | Rabbit Anti-FAP Polyclonal Antibody (MRO-1853-CN) | WB, IF, FC | Rabbit IgG |
| HPAB-A1368-YJ | Mouse Anti-FAP Recombinant Antibody (clone F19) | ELISA, FuncS, RIA, IP, IF, IHC, IA, Block | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0170-CN-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0170-CN-S(P)) | ELISA, IF | Human scFv |
| HPAB-0176-CN-S(P) | Mouse Anti-FAP Recombinant Antibody (clone cF19); scFv Fragment | ELISA, FC, IHC, IP, IF | Mouse scFv |
| HPAB-0668-YJ-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0668-YJ-S(P)) | ELISA, Inhib, IHC, IF, FuncS | Human scFv |
| HPAB-2061-FY-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-2061-FY-S(P)) | FC, ELISA, IF | Human scFv |
| HPAB-2062-FY-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-2062-FY-S(P)) | FC, ELISA, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0170-CN-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-0170-CN-F(E)) | ELISA, IF | Human Fab |
| HPAB-0171-CN-F(E) | Mouse Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-0171-CN-F(E)) | ELISA | Mouse Fab |
| HPAB-0173-CN-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-0173-CN-F(E)) | ELISA | Humanized Fab |
| HPAB-2061-FY-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-2061-FY-F(E)) | FC, ELISA, IF | Human Fab |
| HPAB-2062-FY-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-2062-FY-F(E)) | FC, ELISA, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0619-CN | Recombinant Dromedary Anti-FAP Single Domain Antibody (HPAB-0619-CN) | ELISA | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-211 | Afuco™ Anti-FAP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-211) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0661 | PE-H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-CN0662 | APC-H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-CN0663 | FITC-H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-CN0664 | H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-CN0665 | PE-A*02:01/Human FAP (GLFKCGIAV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY97 | AbPlus™ Anti-FAP Magnetic Beads (ESC14) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY118 | Human Anti-FAP (clone cF19) scFv-Fc Chimera | FC, IHC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY813 | Anti-FAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY2444 | Anti-Human FAP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC379 | CytoStream™ Mouse Anti-FAP Recombinant Antibody (VS13-YC379) | IHC-P, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC109 | Recombinant Anti-FAP Eliminating Antibody, pH-Sensitive (VS-0625-YC109) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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