Mouse Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC128), CDC Enhanced (CAT#: VS-0924-YC128)
The product is a mouse anti-FAS antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets human FAS and includes hexamerization-enhancing mutations that promote hexamer formation to mediate optimal C1q binding and enhance complement-dependent cytotoxicity (CDC).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
Figure 4 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
Specifications
- Immunogen
- Fas antigen
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Antibody hexamer
- Specificity
- Human FAS
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, WB, CDC
- Conjugate
- None
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
- Gene ID
- 355
- UniProt ID
- P25445
- Long Name
- Fas Cell Surface Death Receptor
Related Resources
TNF Signaling Pathway
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A); scFv Fragment | ELISA, WB, IF, FuncS | Human scFv |
| PSBL-723 | Human Anti-FAS Recombinant Antibody (clone E09); scFv Fragment | WB, IF, FuncS | Human scFv |
| PSBL-724 | Human Anti-FAS Recombinant Antibody (clone EP6b-B01); scFv Fragment | WB, FuncS | Human scFv |
| HPAB-0035-YJ-S(P) | Human Anti-FAS Recombinant Antibody (clone h-HFE7A); scFv Fragment | ELISA, Cyt, Apop | Human scFv |
| HPAB-1575WJ-S(P) | Mouse Anti-FAS Recombinant Antibody; scFv Fragment (clone F919-9-18) | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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