Recombinant Human Antibody (HFE7A) is capable of binding to Fas, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-Fas mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-Fas mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Binding Assay to Human Fas-AIC2.
The symbols correspond to h-HFE7A α- (◇), β- (□), γ- (〇), δ- (△), and ζ- (▼). Chimeric HFE7A (■) was used as the positive control. Human IgG1 (●) was used as the negative control. Similar results were obtained with three independent experiments.
Haruyama, H., Ito, S., Miyadai, K., Takahashi, T., Kawaida, R., Takayama, T.,... & Ichikawa, K. (2002). Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab fragment. Biological and Pharmaceutical Bulletin, 25(12), 1537-1545.
Figure 2 Inhibition Assay against the Binding between m-HFE7A and Human Fas-AIC2.
The symbols correspond to h-HFE7A α- (◇), β- (□), γ- (〇), δ- (△), and ζ- (▼). Chimeric HFE7A (■) was used as the positive control. Human IgG1 (●) was used as the negative control. Similar results were obtained with three independent experiments.
Haruyama, H., Ito, S., Miyadai, K., Takahashi, T., Kawaida, R., Takayama, T.,... & Ichikawa, K. (2002). Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab fragment. Biological and Pharmaceutical Bulletin, 25(12), 1537-1545.
Figure 3 Apoptosis Induction Assay against WR19L12a Cells.
The symbols correspond to h-HFE7A α- (◇), β- (□), γ- (〇), δ- (△), and ζ- (▼). Chimeric HFE7A (■) was used as the positive control. Human IgG1 (●) was used as the negative control. Similar results were obtained with three independent experiments.
Haruyama, H., Ito, S., Miyadai, K., Takahashi, T., Kawaida, R., Takayama, T.,... & Ichikawa, K. (2002). Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab fragment. Biological and Pharmaceutical Bulletin, 25(12), 1537-1545.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A); scFv Fragment | ELISA, WB, IF, FuncS | Human scFv |
HPAB-0035-YJ-S(P) | Human Anti-FAS Recombinant Antibody (clone h-HFE7A); scFv Fragment | ELISA, Cyt, Apop | Human scFv |
HPAB-0450-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0450-YJ-S(P)) | ELISA, FC | Rabbit scFv |
HPAB-0451-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0451-YJ-S(P)) | ELISA, FC | Rabbit scFv |
HPAB-AP649-YC-S(P) | Human Anti-FAS Recombinant Antibody (clone F45D9-γ4); scFv Fragment | IHC, FC, ADCC, CDC, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-029WM | Anti-Human FAS Recombinant Antibody (F45D9-γ1) | FC | Human Antibody |
TAB-029WM-S(P) | Anti-Human FAS Recombinant Antibody scFv Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
TAB-029WM-F(E) | Anti-Human FAS Recombinant Antibody Fab Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0201MZ | Chicken Anti-FAS (ab1) Polyclonal IgY | WB | Chicken antibody |
BRD-0202MZ | Chicken Anti-FAS (ab2) Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-767CQ | Mouse Anti-FAS Recombinant Antibody (clone CBL933) | Neut, FC, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-768CQ | Mouse Anti-FAS Recombinant Antibody (clone ZB4) | Block, FC, IHC, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1252 | Hi-Affi™ Rabbit Anti-FAS Recombinant Antibody (clone DS1252AB) | WB, ICC | Rabbit IgG |
MOR-1253 | Hi-Affi™ Rabbit Anti-Fas Recombinant Antibody (clone DS1253AB) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-103LC | Mouse Anti-FAS Recombinant Antibody (clone CH11) | FC, ICC, WB |
CAT | Product Name | Application | Type |
---|---|---|---|
FN-213CQ | Mouse Anti-FAS Recombinant Antibody (clone EOS9.1) | FC, FuncS | Mouse IgM, κ |
ZG-0711F | Mouse Anti-FAS Recombinant Antibody (clone 3.22) | FC | Mouse IgG1 |
VS3-QX412 | Mouse Anti-FAS Recombinant Antibody (clone 4C3-G7-B7-H5) | WB | Mouse IgG1 |
VS3-QX413 | Mouse Anti-FAS Recombinant Antibody (clone 8C1-B9-F12) | WB | Mouse IgG2b |
VS3-XY660 | Mouse Anti-FAS Recombinant Antibody, PE (clone 4ADX2) | FC, IF | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0035-YJ-F(E) | Human Anti-FAS Recombinant Antibody (clone h-HFE7A); Fab Fragment | ELISA, Cyt, Apop | Human Fab |
HPAB-0450-YJ-F(E) | Rabbit Anti-FAS Recombinant Antibody; Fab Fragment (HPAB-0450-YJ-F(E)) | ELISA, FC | Rabbit Fab |
HPAB-AP649-YC-F(E) | Human Anti-FAS Recombinant Antibody (clone F45D9-γ4); Fab Fragment | IHC, FC, ADCC, CDC, FuncS | Human Fab |
HPAB-1575WJ-F(E) | Mouse Anti-FAS Recombinant Antibody; Fab Fragment (clone F919-9-18) | ELISA, WB | Mouse Fab |
HPAB-1576WJ-F(E) | Human Anti-FAS Recombinant Antibody; Fab Fragment (clone F919) | ELISA, WB | Human Fab |
There are currently no Customer reviews or questions for PABL-094. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.