FAS

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For Research Use Only. Not For Clinical Use.


Background

Fas cell surface death receptor is a member of the TNF-receptor superfamily. It contains a death domain. It has been shown to play a crucial role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of FAS with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10.
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