Human Anti-FAS Recombinant Antibody (clone EP6b-B01)
CAT#: PABL-731
Recombinant Human Antibody (EP6b-B01) is capable of binding to TNFR 6, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TNFR 6 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TNFR 6 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody could efficiently trigger apoptosis and therefore function as a potent agonist.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
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Specifications
- Immunogen
- Human Fas cell surface death receptor
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human FAS
- Species Reactivity
- Human
- Clone
- EP6b-B01
- Applications
- WB, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The FAS antibody has been reported in applications of Surface Plasmon Resonance.
Target
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Related Signaling Pathways
TNF Signaling Pathway
Related Diseases
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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|---|---|---|---|
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| HPAB-0450-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0450-YJ-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0451-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0451-YJ-S(P)) | ELISA, FC | Rabbit scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A); Fab Fragment | ELISA, WB, IF, FuncS | Human Fab |
| HPAB-0035-YJ-F(E) | Human Anti-FAS Recombinant Antibody (clone h-HFE7A); Fab Fragment | ELISA, Cyt, Apop | Human Fab |
| HPAB-0450-YJ-F(E) | Rabbit Anti-FAS Recombinant Antibody; Fab Fragment (HPAB-0450-YJ-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0451-YJ-F(E) | Rabbit Anti-FAS Recombinant Antibody; Fab Fragment (HPAB-0451-YJ-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-1575WJ-F(E) | Mouse Anti-FAS Recombinant Antibody; Fab Fragment (clone F919-9-18) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029WM | Anti-Human FAS Recombinant Antibody (F45D9-γ1) | FC | Human Antibody |
| TAB-029WM-S(P) | Anti-Human FAS Recombinant Antibody scFv Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| TAB-029WM-F(E) | Anti-Human FAS Recombinant Antibody Fab Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0201MZ | Chicken Anti-FAS (ab1) Polyclonal IgY | WB | Chicken antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-767CQ | Mouse Anti-FAS Recombinant Antibody (clone CBL933) | Neut, FC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-768CQ | Mouse Anti-FAS Recombinant Antibody (clone ZB4) | Block, FC, IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1252 | Hi-Affi™ Rabbit Anti-FAS Recombinant Antibody (clone DS1252AB) | WB, ICC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-103LC | Mouse Anti-FAS Recombinant Antibody (clone CH11) | FC, ICC, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-213CQ | Mouse Anti-FAS Recombinant Antibody (clone EOS9.1) | FC, FuncS | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0035-YJ | Human Anti-FAS Recombinant Antibody (clone h-HFE7A) | ELISA, Cyt, Apop | Human IgG1, κ |
| HPAB-AP649-YC | Human Anti-FAS Recombinant Antibody (clone F45D9-γ4) | IHC, FC, ADCC, CDC, FuncS | Human IgG4 |
| ZG-0333J | Mouse Anti-FAS Recombinant Antibody (ZG-0333J) | WB | Mouse IgG |
| ZG-0334J | Mouse Anti-FAS Recombinant Antibody (ZG-0334J) | WB | Mouse IgG |
| VS4-WK171 | Mouse Anti-FAS Recombinant Antibody (VS4-WK171) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC127 | Human Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC127), CDC Enhanced | IHC, FC, ADCC, CDC | Antibody hexamer |
| VS-0924-YC128 | Mouse Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC128), CDC Enhanced | ELISA, WB, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC348 | Recombinant Anti-FAS Vesicular Antibody, EV Displayed (VS-0425-YC348) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2448 | Anti-FAS Immunohistochemistry Kit | IHC | |
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