Recombinant Anti-FAS Vesicular Antibody, EV Displayed (VS-0425-YC348)
CAT#: VS-0425-YC348
The Recombinant Anti-FAS Vesicular Antibody, EV Displayed (VS-0425-YC348) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FAS-expressed cells or tissues. The FAS is a receptor involved in apoptosis regulation, interacting with ligands forming death signaling complexes, affecting proliferation and immune processes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FAS
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human, Marmosets, Chimpanzee
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fas cell surface death receptor
- Biological Process
- Apoptosis
- Molecular Function
- Calmodulin-binding, Receptor
- Cellular Localization
- Plasma membrane, Nuclear bodies, Cytosol
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- Alternative Names
- APO-1, APT1, CD95, FAS1, TNFRSF6
- Gene ID
- 355
- UniProt ID
- P25445
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Related Signaling Pathways
TNF Signaling Pathway
Related Diseases
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-723 | Human Anti-FAS Recombinant Antibody (clone E09); Fab Fragment | WB, IF, FuncS | Human Fab |
| PFBL-724 | Human Anti-FAS Recombinant Antibody (clone EP6b-B01); Fab Fragment | WB, FuncS | Human Fab |
| HPAB-0450-YJ-F(E) | Rabbit Anti-FAS Recombinant Antibody; Fab Fragment (HPAB-0450-YJ-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0451-YJ-F(E) | Rabbit Anti-FAS Recombinant Antibody; Fab Fragment (HPAB-0451-YJ-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-AP649-YC-F(E) | Human Anti-FAS Recombinant Antibody (clone F45D9-γ4); Fab Fragment | IHC, FC, ADCC, CDC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029WM | Anti-Human FAS Recombinant Antibody (F45D9-γ1) | FC | Human Antibody |
| TAB-029WM-S(P) | Anti-Human FAS Recombinant Antibody scFv Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| TAB-029WM-F(E) | Anti-Human FAS Recombinant Antibody Fab Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0201MZ | Chicken Anti-FAS (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0202MZ | Chicken Anti-FAS (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-767CQ | Mouse Anti-FAS Recombinant Antibody (clone CBL933) | Neut, FC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-768CQ | Mouse Anti-FAS Recombinant Antibody (clone ZB4) | Block, FC, IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1252 | Hi-Affi™ Rabbit Anti-FAS Recombinant Antibody (clone DS1252AB) | WB, ICC | Rabbit IgG |
| MOR-1253 | Hi-Affi™ Rabbit Anti-Fas Recombinant Antibody (clone DS1253AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-103LC | Mouse Anti-FAS Recombinant Antibody (clone CH11) | FC, ICC, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-213CQ | Mouse Anti-FAS Recombinant Antibody (clone EOS9.1) | FC, FuncS | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1575WJ | Mouse Anti-FAS Recombinant Antibody (clone F919-9-18) | ELISA, WB | Mouse IgG |
| HPAB-1576WJ | Human Anti-FAS Recombinant Antibody (clone F919) | ELISA, WB | Human IgG |
| ZG-0768F | Mouse Anti-FAS Recombinant Antibody (clone B-R18) | FC | Mouse IgG1 |
| VS3-QX412 | Mouse Anti-FAS Recombinant Antibody (clone 4C3-G7-B7-H5) | WB | Mouse IgG1 |
| VS4-WK171 | Mouse Anti-FAS Recombinant Antibody (VS4-WK171) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC127 | Human Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC127), CDC Enhanced | IHC, FC, ADCC, CDC | Antibody hexamer |
| VS-0924-YC128 | Mouse Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC128), CDC Enhanced | ELISA, WB, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2448 | Anti-FAS Immunohistochemistry Kit | IHC | |
| VS-0525-XY2449 | Anti-Human FAS Immunohistochemistry Kit | IHC |
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