Human Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC127), CDC Enhanced (CAT#: VS-0924-YC127)
This product is a human anti-FAS antibody hexamer with enhanced Complement-Dependent Cytotoxicity (CDC) activity. The hexameric IgG1, which targets human, marmoset, and chimpanzee FAS, includes hexamerization-enhancing mutations that promote hexamer formation. This design allows for optimal C1q binding, thereby enhancing CDC.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
Figure 4 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
Specifications
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human, Marmoset and Chimpanzee FAS
- Species Reactivity
- Human, Marmoset, Chimpanzee
- Molecule Class
- ~ 900 kDa
- Applications
- IHC, FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Diseases involving apoptosis
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Fas Cell Surface Death Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Fas (TNF Receptor Superfamily, Member 6); Apoptosis-Mediating Surface Antigen FAS; TNF Receptor Superfamily Member 6; FASLG Receptor; CD95 Antigen; TNFRSF6; APT1; FAS1; Mutant Tumor Necrosis Receptor Superfamily Member 6
- Gene ID
- 355
- UniProt ID
- P25445
- Long Name
- Fas Cell Surface Death Receptor
Related Resources
TNF Signaling Pathway
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Hexamer Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1160z | Mouse Anti-FAS Recombinant Antibody (clone 26D10) | WB, FC, IP, FuncS | Mouse IgG3 |
| PABL-730 | Human Anti-FAS Recombinant Antibody (PABL-730) | WB, IF, FuncS | Human IgG |
| PABL-731 | Human Anti-FAS Recombinant Antibody (clone EP6b-B01) | WB, FuncS | Human IgG |
| FN-038CQ | Mouse Anti-FAS Recombinant Antibody (clone APO-1-3) | FC, IP, WB, FuncS | Mouse IgG3 |
| ZG-0333J | Mouse Anti-FAS Recombinant Antibody (ZG-0333J) | WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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