Mouse Anti-IL18 Recombinant Antibody (clone 13G9) (CAT#: HPAB-0062-YJ)
This product is a recombinant mouse antibody that recognizes human IL-18. Mab 13G9 is useful in the treatment and diagnosis of conditions mediated by IL-18. It can be used in the treatment of inflammatory bowel disease, arthritis, psoriatics.
Specific Inquiry
Inhib
Figure 3 IL-18 inhibits RM1 tumor growth.
IL-18 expression by RM1 murine prostate carcinoma cells inhibits the in vivo growth of these cells implanted subcutaneously and orthotopically into syngeneic mice.
Tse, B. W. C., Russell, P. J., Lochner, M., Förster, I., & Power, C. A. (2011). IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms. PLoS One, 6(9), e24241.
FC
Figure 4 Tumor-draining lymph nodes of normal C57BL/6 mice with orthotopic RM1-IL18 tumors show increased cellularity but a decrease in lymphocytes as a percentage of total cells when IL-18 is neutralized as assessed by flow-cytometry.
Results shown are for pooled para-aortic lymph nodes from normal C57BL/6 mice.
Tse, B. W. C., Russell, P. J., Lochner, M., Förster, I., & Power, C. A. (2011). IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms. PLoS One, 6(9), e24241.
Specifications
- Immunogen
- Recombinant IL-18
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human IL18
- Species Reactivity
- Human
- Clone
- 13G9
- Applications
- Inhib, FC, IHC, ELISA
- Related Disease
- Inflammatory Bowel Disease, Arthritis, Psoriatics
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL18 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition, Immunohistochemistry.
Target
- Alternative Names
- Interleukin 18; IGIF; IL-18; IL-1g; IL1F4; IFN-gamma-inducing factor; IL-1 gamma; iboctadekin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; 13G9; MAb 13G9
- Gene ID
- 3606
- UniProt ID
- Q14116
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0373CL | Human Anti-IL18 Recombinant Antibody (TAB-0373CL) | ELISA, FuncS, Inhib | Human IgG |
| TAB-0374CL | Human Anti-IL18 Recombinant Antibody (TAB-0374CL) | ELISA, FuncS, Inhib | Human IgG |
| TAB-0373CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0373CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
| TAB-0374CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0374CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
| TAB-0373CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0373CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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