This product is a recombinant mouse antibody that recognizes human IL-18. Mab 13G9 is useful in the treatment and diagnosis of conditions mediated by IL-18. It can be used in the treatment of inflammatory bowel disease, arthritis, psoriatics.
Figure 1 Representative standard curve of IL-18 ELISA.
Results represent mean±SEM from at leastthree independent experiments.
Muneta, Y., Mikami, O., Shimoji, Y., Nakajima, Y., Yokomizo, Y., & Mori, Y. (2000). Detection of porcine interleukin-18 by sandwich ELISA and immunohistochemical staining using its monoclonal antibodies. Journal of Interferon & Cytokine Research, 20(3), 331-336.
Figure 2 Immunohistochemical staining of IL-18 using a mAb 13G9.
No positive reaction is observed. Bars=50 um.
Muneta, Y., Mikami, O., Shimoji, Y., Nakajima, Y., Yokomizo, Y., & Mori, Y. (2000). Detection of porcine interleukin-18 by sandwich ELISA and immunohistochemical staining using its monoclonal antibodies. Journal of Interferon & Cytokine Research, 20(3), 331-336.
Figure 3 IL-18 inhibits RM1 tumor growth.
IL-18 expression by RM1 murine prostate carcinoma cells inhibits the in vivo growth of these cells implanted subcutaneously and orthotopically into syngeneic mice.
Tse, B. W. C., Russell, P. J., Lochner, M., Förster, I., & Power, C. A. (2011). IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms. PLoS One, 6(9), e24241.
Figure 4 Tumor-draining lymph nodes of normal C57BL/6 mice with orthotopic RM1-IL18 tumors show increased cellularity but a decrease in lymphocytes as a percentage of total cells when IL-18 is neutralized as assessed by flow-cytometry.
Results shown are for pooled para-aortic lymph nodes from normal C57BL/6 mice.
Tse, B. W. C., Russell, P. J., Lochner, M., Förster, I., & Power, C. A. (2011). IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms. PLoS One, 6(9), e24241.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1332z | Mouse Anti-IL18 Recombinant Antibody (clone 27G4) | WB, IF, ELISA | Mouse IgG2b |
HPAB-0066-YC | Human Anti-IL18 Recombinant Antibody (HPAB-0066-YC) | Neut | Humanized IgG2 |
HPAB-0067-YC | Rat Anti-IL18 Recombinant Antibody (clone 2C10) | Neut | Rat IgG |
HPAB-0065-YC | Human Anti-IL18 Recombinant Antibody (clone LT28) | ELISA, RIA, IHC, FuncS, Neut | Human IgG |
HPAB-1273LY | Human Anti-IL18 Recombinant Antibody (HPAB-1273LY) | IHC, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0373CL | Human Anti-IL18 Recombinant Antibody (TAB-0373CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0374CL | Human Anti-IL18 Recombinant Antibody (TAB-0374CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0373CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0373CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
TAB-0374CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0374CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
TAB-0373CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0373CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0290MZ | Chicken Anti-Interleukin-18 Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1238CQ | Rabbit Anti-IL18 Recombinant Antibody (clone 1072F) | Neut | Rabbit IgG |
NEUT-1239CQ | Rat Anti-Il18 Recombinant Antibody (clone 39-3F) | Neut, WB | Rat IgG2a |
NEUT-1240CQ | Mouse Anti-IL18 Recombinant Antibody (clone CBL670) | Neut | Mouse IgG2a |
NEUT-1241CQ | Rat Anti-Il18 Recombinant Antibody (clone YIGIF74-1G7) | Neut | Rat IgG2a |
NEUT-1242CQ | Rat Anti-Il18 Recombinant Antibody (clone 93-10C) | IP, Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4248 | Rabbit Anti-IL18 Recombinant Antibody (clone SI327DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0065-YC-S(P) | Human Anti-IL18 Recombinant Antibody (clone LT28); scFv Fragment | ELISA, RIA, IHC, FuncS, Neut | Human scFv |
HPAB-0092-WJ-S(P) | Human Anti-IL18 Recombinant Antibody (clone 2.5(E)); scFv Fragment | ELISA | Human scFv |
HPAB-1558-FY-F(E) | Human Anti-IL18 Recombinant Antibody (clone H1L2); scFv Fragment | ELISA | Human scFv |
HPAB-J0129-YC-S(P) | Human Anti-IL18 Recombinant Antibody (clone ABT-325); scFv Fragment | ELISA | Human scFv |
FAMAB-0041JF-S(P) | Human Anti-IL18 Recombinant Antibody (clone h18-108); scFv Fragment | IB, FC, ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0064-YC-F(E) | Human Anti-IL18 Recombinant Antibody (clone 2E1); Fab Fragment | ELISA, RIA, IHC, FuncS, Neut | Human Fab |
HPAB-0066-YC-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-0066-YC-F(E)) | Neut | Humanized Fab |
HPAB-0067-YC-F(E) | Rat Anti-IL18 Recombinant Antibody (clone 2C10); Fab Fragment | Neut | Rat Fab |
HPAB-0855-FY-S(P) | Human Anti-IL18 Recombinant Antibody (clone 2.5); Fab Fragment | ELISA | Human Fab |
HPAB-0856-FY-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0856-FY-S(P)) | Inhib | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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