Anti-IL2 (clone JES6-1) Recombinant Antibody Coupled Liposome (VS-1024-FY18) (CAT#: VS-1024-FY18)
Anti-IL-2-conjugated liposomes may have the potential to selectively target and kill T cells, as they can induce the proliferation and activity of T cells. Studies have shown that IL-2-conjugated liposomes not only effectively target extracellular tumor-reactive T cells but may also enhance the effects of immunotherapy. However, IL-2 can also stimulate regulatory T cells, which may potentially limit its effectiveness as a cancer treatment.
More Infomation
Normal Tissue
RNA Expression
Figure 1 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Figure 2 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
Figure 4 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- JES6-1
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Mouse
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was specifically engineered to target interleukin-2 (IL-2). IL-2 is a pivotal cytokine in the immune system, primarily produced by activated T cells, and plays a crucial role in the regulation of immune responses, T cell proliferation, and differentiation.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL2
- Introduction
- Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.
- Alternative Names
- Interleukin-2; IL-2; bovine IL-2
- Full Name
- Interleukin-2
- Sequence Similarities
- Belongs to the IL-2 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Thr23 (NX_P60568 [NX_P60568-1])
Modification sites at PhosphoSitePlus (P60568)
Glycosylation from GlyConnect IL2_HUMAN (225, 297, 298, 299, 300)
Glycosylation from GlyGen (P60568) 2 sites, 11 N-linked glycans (1 site), 9 O-linked glycans (2 sites)
- Protein Refseq
- NP_000577.2
- Function
- Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well (PubMed:6608729).
Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production (PubMed:6438535).
Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.
Related Resources
Autoimmune Thyroid Disease
Maturity Onset Diabetes of the Young
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone JES6-1"
See other products for "Il2"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products
Humanized Antibody Products
ScFv Antibody Products
Human Antibody Products
Mouse Antibody Products
Deglycosylated Antibody Products
Chicken IgY Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
Fab Antibody Products
IgG Antibody Products
Non-Human Primate (NHP) Antibody Products
Flow Cytometry (FC) related Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-093 | Recombinant Anti-Mouse Il2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-1024-FY18. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
-1.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, ELISA, FuncS
Application: WB, ELISA, FuncS
![Figure 1 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in SDS-PAGE](https://img.creativebiolabs.net/productimages/COA-TAB-1611CL-F(E)-1.png)
Application: Depletion, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
-1.jpg)
Application: FC, FuncS, IA, IF, IP, IHC
-1.png)
Application: ELISA
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: Inhib, FC, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
