Anti-IL2 (clone JES6-1) Recombinant Antibody Coupled Liposome (VS-1024-FY18)
CAT#: VS-1024-FY18
Anti-IL-2-conjugated liposomes may have the potential to selectively target and kill T cells, as they can induce the proliferation and activity of T cells. Studies have shown that IL-2-conjugated liposomes not only effectively target extracellular tumor-reactive T cells but may also enhance the effects of immunotherapy. However, IL-2 can also stimulate regulatory T cells, which may potentially limit its effectiveness as a cancer treatment.
Gene Expression
Normal Tissue
Figure 1 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
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More Infomation
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- JES6-1
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Mouse
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was specifically engineered to target interleukin-2 (IL-2). IL-2 is a pivotal cytokine in the immune system, primarily produced by activated T cells, and plays a crucial role in the regulation of immune responses, T cell proliferation, and differentiation.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL2
- Introduction
- Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.
- Alternative Names
- Interleukin-2; IL-2; bovine IL-2
- Full Name
- Interleukin-2
- Sequence Similarities
- Belongs to the IL-2 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Thr23 (NX_P60568 [NX_P60568-1])
Modification sites at PhosphoSitePlus (P60568)
Glycosylation from GlyConnect IL2_HUMAN (225, 297, 298, 299, 300)
Glycosylation from GlyGen (P60568) 2 sites, 11 N-linked glycans (1 site), 9 O-linked glycans (2 sites)
- Protein Refseq
- NP_000577.2
- Function
- Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well (PubMed:6608729).
Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production (PubMed:6438535).
Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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