Afuco™ Anti-ITGA4 ADCC Recombinant Antibody (Etrolizumab), ADCC Enhanced (CAT#: AFC-TAB-135)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to integrin alpha 4 beta 7. Etrolizumab is a humanized monoclonal antibody designed for the treatment of inflammatory bowel disease.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from rat)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Etrolizumab
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Etrolizumab
- Related Disease
- Ulcerative colitis (UC)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Etrolizumab; 1044758-60-2; rhuMAb Beta7; Anti-beta7; PRO145223; RG7413; ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); CD49D; integrin alpha-4; CD49d; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha;
- Gene ID
- 3676
- UniProt ID
- P13612
Related Resources
Please refer to Etrolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Etrolizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Etrolizumab"
Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab)Recombinant monoclonal antibody to integrin alpha 4 beta 7. Etrolizumab is a humanized monoclonal antibody designed for the treatment of inflammatory bowel disease.
See other products for "ITGA4"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-135 | Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L029G | anti-ITGA4 immunotoxin 15A8 (IgG)-Gel | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6) | Neut, FuncS | Human IgG |
| MOB-1193MZ | Recombinant Mouse Anti-Human ITGA4 Antibody (clone 55I7) | FC, IHC-Fr, IP, WB | Mouse antibody |
| MRO-0848-CN | Recombinant Rabbit Anti-ITGA4 Monoclonal Antibody (JA09-36) | WB, IHC, FC | Rabbit IgG |
| VS3-QX606 | Mouse Anti-ITGA4 Recombinant Antibody (clone 5C4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK1481 | Mouse Anti-ITGA4 Recombinant Antibody (clone K49) | FC, IF | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6); scFv Fragment | Neut, FuncS | Human scFv |
| PSBL-360 | Human Anti-ITGA4 Recombinant Antibody (clone HP1/2); scFv Fragment | FC, ELISA, FuncS | Human scFv |
| HPAB-0466-YJ-S(P) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); scFv Fragment | ELISA, FC, Block | Human scFv |
| HPAB-1588WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone TA2) | ELISA, WB | Mouse scFv |
| HPAB-1620WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone HP1 / 2) | ELISA, WB | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6); Fab Fragment | Neut, FuncS | Human Fab |
| HPAB-0466-YJ-F(E) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); Fab Fragment | ELISA, FC, Block | Human Fab |
| HPAB-1588WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone TA2) | ELISA, WB | Mouse Fab |
| HPAB-1620WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone HP1 / 2) | ELISA, WB | Mouse Fab |
| HPAB-1621WJ-F(E) | Human Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone huHP1 / 2) | ELISA, WB | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-717LC | Anti-human ITGA4 Recombinant Antibody (IN 10) (TAB-717LC) | ELISA | Human antibody |
| TAB-717LC-S(P) | Anti-human ITGA4 scFv Fragment (IN 10) | ELISA | Human antibody |
| TAB-717LC-F(E) | Anti-human ITGA4 Fab Fragment (IN 10) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-122 | Recombinant Mouse Anti-Integrin alpha 4 Antibody (ACT-1) | Neut, FuncS | IgG |
| PABX-122-S (P) | Recombinant Mouse Anti-Integrin alpha 4 Antibody scFv Fragment (ACT-1) | Neut, FuncS | scFv |
| PABX-122-F (E) | Recombinant Mouse Anti-Integrin alpha 4 Antibody Fab Fragment (ACT-1) | Neut, FuncS | Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1549CQ | Recombinant Mouse Anti-ITGA4 Antibody (2B4) | BL | IgG1 |
| NEUT-1550CQ | Recombinant Rat Anti-Itga4 Antibody (9C10(MFR4.B)) | FC, BL, IHC | IgG2a, κ |
| NEUT-1551CQ | Recombinant Rat Anti-Itga4 Antibody (R1-2) | FC, IP, BL, IHC | IgG2b, κ |
| NEUT-1552CQ | Recombinant Rat Anti-Itga4 Antibody (PS/2) | FC, BL | IgG2b |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1553CQ | Recombinant Rat Anti-Itga4 Antibody (CBL914) | FC, Neut | IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1873 | Hi-Affi™ Recombinant Rabbit Anti-ITGA4 Monoclonal Antibody (DS1873AB) | ICC/IF, IHC-P, IP, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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