Anti-KDR Antibody-Cytokine Fusion Protein, VHH (3VGR19)-mutIL2
CAT#: VS-0624-FY76
3VGR19 is a sdAb that effectively inhibits the formation of capillary-like structures. IL-2 plays an important role in key functions of the immune system, tolerance, and immunity, primarily through its direct effects on T cells. This product is a novel sdAb-based immunocytokine of a mutant interleukin-2. It was developed with the incorporation of an anti-VEGFR2 sdAb and mutant IL2 gene. This product is a novel sdAb-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic. The binding affinity of VGRmIL2-IC to VEGFR2 was assessed through flow cytometry. A cell concentration of 1 × 10⁶ cells/ml was treated with 1 µg of VGRmIL2-IC for 1 hour at low temperature. This compound demonstrated a specific binding capacity to VEGFR2-positive cells.






Specifications
- Target
- VEGFR2
- Molecule Class
- VHH-mutIL2
- Species Reactivity
- Human
- Clone
- 3VGR19
- Related Disease
- Cancer
- Cytokine 1
- mutant IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activity of white blood cells (leukocytes, usually lymphocytes) responsible for immunity.
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
- Alternative Names
- Kinase Insert Domain Receptor; Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase); Vascular Endothelial Growth Factor Receptor 2; Protein-Tyrosine Kinase Receptor Flk-1; Fetal Liver Kinase 1; EC 2.7.10.1; VEGFR2; FLK1; Tyrosine Kinase Growth Factor Receptor; VGRmIL2-IC
- Gene ID
- 3791
- UniProt ID
- P35968
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Datasheet
MSDS
COA
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