Anti-KDR Antibody-Cytokine Fusion Protein, VHH (3VGR19)-mutIL2 (CAT#: VS-0624-FY76)

• Target
• VEGFR2

• Molecule Class
• VHH-mutIL2

• Species Reactivity
• Human

• Clone
• 3VGR19

• Related Disease
• Cancer

• Cytokine 1
• mutant IL2

• Cytokines 1 Description
• Interleukin-2 (IL-2) is an interleukin, a cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activity of white blood cells (leukocytes, usually lymphocytes) responsible for immunity.

• Cytokine 1 Species
• Human

• Applications
• This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

• Alternative Names
• Kinase Insert Domain Receptor; Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase); Vascular Endothelial Growth Factor Receptor 2; Protein-Tyrosine Kinase Receptor Flk-1; Fetal Liver Kinase 1; EC 2.7.10.1; VEGFR2; FLK1; Tyrosine Kinase Growth Factor Receptor; VGRmIL2-IC

• Gene ID
• 3791

• UniProt ID
• P35968

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