Human Anti-MET Recombinant Antibody (PABC-457)

Name: Human Anti-MET Recombinant Antibody (PABC-457)
SKU: PABC-457
Rating: 5 (1 reviews)

CAT#: PABC-457

This product is a recombinant human antibody that can recognize MET. The antibody inhibited HGF/SF-induced cell migration and proliferation in vitro and inhibited growth of tumor xenografts in vivo. The antibody competes with both HGF/SF and its truncated splice variant NK1 for MET binding, despite the location of the antibody epitope on a domain (Ig1) not reported to bind NK1 or HGF/SF.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

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Specifications

Host Species
Human

Derivation
Human

Type
Human IgG1, κ

Specificity
Human MET

Species Reactivity
Human

Applications
Block, FuncS, ELISA

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
This antibody has been reported for use in Blocking, Functional Assay and Enzyme-linked Immunosorbent Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

Alternative Names
HGFR; AUTS9; RCCP2; c-Met; DFNB97

Gene ID
4233

UniProt ID
P08581

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - PABC-457.pdf

MSDS

MSDS - PABC-457.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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CAT	Product Name	Application	Type
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TAB-537LC	Human Anti-MET Recombinant Antibody (TAB-537LC)	Inhib	Human IgG2
TAB-538LC	Human Anti-MET Recombinant Antibody (TAB-538LC)	Inhib	Human IgG2
TAB-539LC	Human Anti-MET Recombinant Antibody (TAB-539LC)	Inhib	Human IgG2
TAB-540LC	Human Anti-MET Recombinant Antibody (TAB-540LC)	ELISA	Human antibody

CAT	Product Name	Application	Type
TAB-002MZ	Anti-Human MET Recombinant Antibody (TAB-002MZ)	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-002MZ-S(P)	Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P))	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-002MZ-F(E)	Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E))	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-0880CLV-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E))	ELISA, FuncS	Chimeric (mouse/human) Fab
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HPAB-1300LY	Human Anti-MET Recombinant Antibody (HPAB-1300LY)	ELISA, IP	Human IgG2
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HPAB-1299LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1299LY-S(P))	ELISA, IP	Human scFv
HPAB-1300LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1300LY-S(P))	ELISA, IP	Human scFv
HPAB-1301LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1301LY-S(P))	ELISA, IP	Human scFv

CAT	Product Name	Application	Type
HPAB-1298LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E))	ELISA, IP	Human Fab
HPAB-1299LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E))	ELISA, IP	Human Fab
HPAB-1300LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E))	ELISA, IP	Human Fab
HPAB-1301LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E))	ELISA, IP	Human Fab
HPAB-1302LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E))	ELISA, IP	Human Fab

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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application
VS-0325-XY1336	Anti-MET Immunohistochemistry Kit	IHC
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VS-0525-XY4356	Anti-Human MET Immunohistochemistry Kit	IHC

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CAT	Product Name	Application	Type
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