Monkey Anti-MOG Recombinant Antibody (clone M12E) (CAT#: FAMAB-0228JF)
Recombinant monoclonal antibody specially binds to myelin oligodendrocyte glycoprotein (MOG). This monkey anti-MOG antibody (M12E) can be useful in the study of molecular mechanisms required for the production of potentially demyelinating antibodies in humans.
Specific Inquiry
IHC
Figure 1 Immunohistochemical analyses of inflammation, demyelination, and complement activation.
There is profound loss of MOG immunoreactivity at the active site of the lesion; MOG-positive granules can be seen in the cytoplasm of macrophages (early active lesion).
Spadaro, M., Gerdes, L. A., Mayer, M. C., Ertl‐Wagner, B., Laurent, S., Krumbholz, M., ... & Hohlfeld, R. (2015). Histopathology and clinical course of MOG‐antibody‐associated encephalomyelitis. Annals of clinical and translational neurology, 2(3), 295-301.
ELISA
Figure 2 IgG reactivity against rhMOG125 and TT in HC and MS patients as assessed by solid-phase ELISA.
Statistical analysis by unpaired, two-tailed t-test.
Menge, T., von Büdingen, H. C., Lalive, P. H., & Genain, C. P. (2007). Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid‐phase ELISA. European journal of immunology, 37(11), 3229-3239.
WB
Figure 3 Assessment of dimer/multimer formation of soluble rhMOG125 and the resulting antigenicity in immunoblot.
Native Western blot of rhMOG125 after native PAGE.
Menge, T., von Büdingen, H. C., Lalive, P. H., & Genain, C. P. (2007). Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid‐phase ELISA. European journal of immunology, 37(11), 3229-3239.
Specifications
- Immunogen
- Recombinant protein corresponding to the extracellular domain of rat MOGaa1-125
- Host Species
- Monkey
- Derivation
- C. jacchus marmosets phage display Fab library
- Type
- Monkey Fab
- Specificity
- Rat MOG
- Species Reactivity
- Rat
- Clone
- M12E
- Applications
- WB, ELISA, IHC
- Related Disease
- Multiple sclerosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The MOG antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- MOG; myelin oligodendrocyte glycoprotein
- Gene ID
- 24558
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-670 | Recombinant Anti-human MOG Antibody | WB, FC, FuncS | IgG |
| FAMAB-0006WJ | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5) | IF, FC, ELISA | Chimeric (mouse/human) IgG |
| FAMAB-1469CQ | Human Anti-MOG Recombinant Antibody (clone M45) | ELISA | Human IgG1 |
| FAMAB-1470CQ | Human Anti-MOG Recombinant Antibody (clone M3-24) | ELISA | Human IgG1 |
| FAMAB-1471CQ | Human Anti-MOG Recombinant Antibody (clone M38) | ELISA | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-670-F(E) | Recombinant Anti-human MOG Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| MHH-670-F(E) | Recombinant Human Anti-human MOG Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| PFBZ-152 | Mouse Anti-MOG Recombinant Antibody (clone 8-18C5); Fab Fragment | WB | Mouse Fab |
| HPAB-1774-FY-S(P) | Human Anti-MOG Recombinant Antibody (clone AB138); Fab Fragment | Neut | Chimeric (marmoset/human) Fab |
| FAMAB-0006WJ-F(E) | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-670-S(P) | Recombinant Human Anti-human MOG Antibody scFv Fragment | FC, ELISA, FuncS | scFv |
| PSBZ-152 | Mouse Anti-MOG Recombinant Antibody (clone 8-18C5); scFv Fragment | WB | Mouse scFv |
| HPAB-1774-FY-F(E) | Monkey Anti-MOG Recombinant Antibody (clone AB138); scFv Fragment | Neut | Mouse scFv |
| FAMAB-0228JF-S(P) | Monkey Anti-MOG Recombinant Antibody (clone M12E); scFv Fragment | ELISA, FuncS | Monkey scFv |
| FAMAB-0229JF-S(P) | Monkey Anti-MOG Recombinant Antibody (clone M3-24); scFv Fragment | ELISA, FuncS | Monkey scFv |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC661 | I-Ab/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Tetramer, APC | FC | |
| MHC-LC702 | I-Ab/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Tetramer, PE | FC | |
| MHC-LC926 | IAb/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Monomer | MHC Multimer | |
| MHC-YF1586 | BV421-H-2 IAb/Mouse MOG (GWYRSPFSRVVH) MHC Tetramer | FC |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2266 | Hi-Affi™ Recombinant Rabbit Anti-MOG Monoclonal Antibody (DS2266AB) | WB, IHC, ICC | IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1988 | PE-DRB1*15:01/Human MOG (MEVGWYRPPFSRVVHLYRNGK) MHC Tetramer | FCM | |
| MHC-CN0317 | APC-H-2Db/Human MOG (VGWYRSPFSRVVHL) MHC Tetramer | FCM | |
| MHC-CN0318 | PE-H-2Db/Human MOG (VGWYRSPFSRVVHL) MHC Tetramer | FCM | |
| MHC-YF305 | IAb/Human MOG (GWYRSPFSRVVH) MHC Monomer | MHC Multimer | |
| MHC-YF307 | IAb/Human MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Monomer | MHC Multimer |
MHC Tetramer for Other Applications
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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