Mouse Anti-PCSK9 Recombinant Antibody (clone Ab-3D5) (CAT#: HPAB-0041-WJ)
This product is a mouse monoclonal IgG kappa antibody targeting intact human proprotein convertase subtilisin/kexin type 9 (PCSK9). This antibody binds to an epitope of PCSK9 comprising, consisting essentially of, or consisting of amino acid residues Thr214 an epitope of PCSK9 comprising, consisting essentially of, or consisting of amino acid residues Glu211 through Ala220.
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Inhib
Figure 1 Inhibition of PCSK9 function by Ab-3D5.
B. Ab-3D5 prevents LDL receptor degradation in HepG2 cells. HepG2 cells were treated for 4 h with buffer alone (Ctrl), with PCSK9 alone (-Ab) or with PCSK9 preincubated with increasing concentrations of the non-blocking Ab-7G7 or with Ab3D5. Surface LDL receptor levels were quantified by FACS analysis and expressed as percent of control levels. Values are the average ± SD or three experiments.
Lipari, M. T., Li, W., Moran, P., Kong-Beltran, M., Sai, T., Lai, J., ... & Arnott, D. (2012). Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. Journal of Biological Chemistry, 287(52), 43482-43491.
Specifications
- Immunogen
- Recombinant PCSK9 wildtype
- Host Species
- Mouse
- Type
- Mouse IgG, κ
- Specificity
- Human PCSK9
- Species Reactivity
- Human
- Clone
- Ab-3D5
- Applications
- ELISA, WB, Inhib
- Related Disease
- Coronary heart disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The PCSK9 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Western Blot, Inhibition.
Target
- Alternative Names
- PCSK9; Hypercholesterolemia, Autosomal Dominant 3; HCHOLA3; EC 3.4.21.-; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; NARC-1; Proprotein Convertase 9
- Gene ID
- 255738
- UniProt ID
- Q8NBP7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-097 | Recombinant Anti-human PCSK9 VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-0083CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0083CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0084CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0084CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0085CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0085CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0086CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0086CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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