Mouse Anti-RTN4 Recombinant Antibody (clone 6F2) (CAT#: HPAB-0047-WJ)
This product is a mouse monoclonal antibody targeting reticulon 4B (RTN4B). This antibody inhibits the growth of cancer cells and is expected for clinical anti-cancer therapy.
Specific Inquiry
Inhib
Figure 1 Anti‐Nogo‐B antibody 6F2 suppresses angiogenesis in vitro.
(A) The cell adhesion blockage assay in which HUVECs were incubated with mAb 6F2 before they were replated on Nogo‐B‐coated surfaces. The error bar represents the SD (n = 3, **P < 0.01).
Cai, H., Saiyin, H., Liu, X., Han, D., Ji, G., Qin, B., ... & Wu, Y. (2018). Nogo‐B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Molecular oncology, 12(12), 2042-2054.
IHC
Figure 2 Anti‐Nogo‐B antibody 6F2 suppresses angiogenesis in vivo.
(D) Immunohistochemical staining with a CD31/PECAM‐1 antibody of tumor sections. Small rectangles (scale bars, 200 μm) are shown at higher magnification in the inner panel (scale bars, 50 μm).
Cai, H., Saiyin, H., Liu, X., Han, D., Ji, G., Qin, B., ... & Wu, Y. (2018). Nogo‐B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Molecular oncology, 12(12), 2042-2054.
IF
Figure 3 Anti‐Nogo‐B antibody 6F2 suppresses angiogenesis in vivo.
(F) Representative photographs of tumor sections co‐immunostained with pFAK, CD31, and nuclear stain. Scale bars, 100 μm.
Cai, H., Saiyin, H., Liu, X., Han, D., Ji, G., Qin, B., ... & Wu, Y. (2018). Nogo‐B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Molecular oncology, 12(12), 2042-2054.
Specifications
- Immunogen
- Polypeptide RTN4B
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human RTN4B
- Species Reactivity
- Human
- Clone
- 6F2
- Applications
- ELISA, WB, Inhib, IHC, IF
- Related Disease
- Lung cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The RTN4 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Western Blot, Inhibition, Immunohistochemistry, Immunofluorescence.
Target
- Alternative Names
- RTN4; RTN4-B1; RTN4-A; KIAA0886; Nogo-B; NOGOC; Neuroendocrine-Specific Protein; NI220/250; NOGO; Nbla00271; RTN-X; Nogo-C; Nbla10545; Neurite Growth Inhibitor 220; NSP; Nogo Protein; Neurite Outgrowth Inhibitor; Human NogoA; Foocen; ASY
- Gene ID
- 57142
- UniProt ID
- Q9NQC3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Fab Antibody Products
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2437z | Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-186CQ | Mouse Anti-RTN4 Antibody | ELISA, WB | Mouse IgG1 |
| HPAB-0294CQ | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6) | ELISA, WB | Mouse IgG1 |
| MRO-1101-CN | Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (JM02-34) | WB, IF, IHC, IP, FC | Rabbit IgG |
| HPAB-0901-FY | Human Anti-RTN4 Recombinant Antibody (HPAB-0901-FY) | ELISA, Neut | Humanized IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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