Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-M0696-YC-F(E)) (CAT#: HPAB-M0696-YC-F(E))
This product is a recombinant mouse antibody Fab fragment that recognizes SNCA. Its full-length antibody was derived from the hybridoma technology. This Fab antibody specifically binds to an epitope within amino acids 100-117 of human SNCA protein with high affinity. Its binding to SCNA has been validated in ELISA with recombinant human α-synuclein the antigen and in IHC with brain slices of PD patients. In the in vivo animal model, it could disrupt synuclein aggregation and reduce symptoms of Parkinson's disease. This Fab antibody can be humanized and purified by affinity chromatography in immunotherapeutic research of neurodegeneration.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Figure 2 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Figure 5 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
Specifications
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human SNCA
- Species Reactivity
- Human
- Applications
- ELISA, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Synuclein Alpha; Synuclein, Alpha (Non A4 Component Of Amyloid Precursor); Alpha-Synuclein; PARK1; NACP; Parkinson Disease (Autosomal Dominant, Lewy Body) 4; Non A4 Component Of Amyloid Precursor; Non-A4 Component Of Amyloid Precursor;
- Gene ID
- 6622
- UniProt ID
- P37840
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SNCA"
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(A) | Recombinant Anti-human SNCA Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-086 | Recombinant Anti-SNCA VHH Single Domain Antibody (NbSyn2) | WB, FuncS | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0741CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0742CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0742CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0743CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0743CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0744CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0744CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0745CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0745CLV-S(P)) | ELISA | Mouse scFv |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC/IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-005CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| HPAB-N0389-YC-F(E) | Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0389-YC-F(E)) | ELISA, IP, FuncS | Human Fab |
| HPAB-N0390-YC-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0390-YC-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-653-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-653-FY-F(E)) | WB, IP, ELISA | Mouse Fab |
| HPAB-654-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-654-FY-F(E)) | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0260-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone D10); scFv Fragment | ELISA | Human scFv |
| FAMAB-0261-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone 6E); scFv Fragment | ELISA | Human scFv |
| HPAB-653-FY-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-653-FY-S(P)) | WB, IP, ELISA | Mouse scFv |
| HPAB-654-FY-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-654-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-M0696-YC-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-M0696-YC-S(P)) | ELISA, FuncS | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023-FY | Mouse Anti-SNCA Recombinant Antibody (HPAB-0023-FY) | ELISA | Mouse IgG1, κ |
| HPAB-N0389-YC | Human Anti-SNCA Recombinant Antibody (HPAB-N0389-YC) | ELISA, IP, FuncS | Human IgG |
| HPAB-N0390-YC | Mouse Anti-SNCA Recombinant Antibody (HPAB-N0390-YC) | ELISA, IP, FuncS | Mouse IgG |
| VS3-QX1037 | Mouse Anti-SNCA Recombinant Antibody (clone 9H12) | ELISA | Mouse IgG1 |
| VS3-QX1038 | Mouse Anti-SNCA Recombinant Antibody (clone 2E2) | IHC, ELISA | Mouse IgG1 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-M0696-YC-F(E). Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.