Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0389-YC-F(E)) (CAT#: HPAB-N0389-YC-F(E))
This product is a recombinant human antibody Fab fragment that recognizes SNCA, a protein directly associated with Lewy body diseases. This Fab antibody could target and immunoprecipitate low molecular weight, spliced or truncated SNCA. Thus, it could recognize the pathological aggregated forms of SNCA and inhibit the pathological accumulation of SNCA in primary cortical neurons. This anti-SNCA Fab antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography with a purity higher than 95%.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Figure 2 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Figure 5 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human Fab
- Specificity
- Human SNCA
- Species Reactivity
- Human
- Applications
- ELISA, IP, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SNCA"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1365z | Mouse Anti-SNCA Recombinant Antibody (clone 8F8) | ELISA, FC, ICC, IF, WB | Mouse IgG1 |
| MOB-0599MZ | Recombinant Mouse Anti-Human SNCA Antibody (clone 20D4) | ELISA, WB | Mouse antibody |
| MRO-2298-CN | Recombinant Rabbit Anti-SNCA (phosphorylated Ser129) Monoclonal Antibody (JB22-44) | WB, IF, IHC | Rabbit IgG |
| VS-0323-CJ51 | Human Anti-SNCA Recombinant Antibody (clone pF) | ELISA, WB, IF, IHC, DB, Inhib, Cyt, FuncS | Human IgG |
| VS-0323-CJ52 | Human Anti-SNCA Recombinant Antibody (clone Pc) | ELISA, WB, IF, IHC, DB, Inhib, Cyt, FuncS | Human IgG |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(A) | Recombinant Anti-human SNCA Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-086 | Recombinant Anti-SNCA VHH Single Domain Antibody (NbSyn2) | WB, FuncS | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0741CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0742CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0742CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0743CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0743CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0744CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0744CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0745CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0745CLV-S(P)) | ELISA | Mouse scFv |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC/IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-005CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| NS-088CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-088CN-S(P)) | WB, ELISA, IHC | Mouse scFv |
| FAMAB-0260-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone D10); scFv Fragment | ELISA | Human scFv |
| FAMAB-0261-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone 6E); scFv Fragment | ELISA | Human scFv |
| HPAB-N0389-YC-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0389-YC-S(P)) | ELISA, IP, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0260-CN-F(E) | Human Anti-SNCA Recombinant Antibody (clone D10); Fab Fragment | ELISA | Human Fab |
| FAMAB-0261-CN-F(E) | Human Anti-SNCA Recombinant Antibody (clone 6E); Fab Fragment | ELISA | Human Fab |
| HPAB-N0390-YC-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-N0390-YC-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-653-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-653-FY-F(E)) | WB, IP, ELISA | Mouse Fab |
| HPAB-654-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-654-FY-F(E)) | ELISA | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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