Human Anti-MAPT (clone IPN002) scFv-Fc Chimera
CAT#: VS-0325-FY121
The anti-MAPT scFv-Fc antibody targets Microtubule-Associated Protein Tau (MAPT), a protein implicated in neurodegenerative diseases such as Alzheimer's disease. It is designed to bind specifically to abnormal forms of MAPT, potentially aiding in the clearance of toxic aggregates. This antibody has potential applications in the treatment and diagnosis of tauopathies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining:
Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MAPT
- Species Reactivity
- Human
- Clone
- IPN002
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU
- Gene ID
- 4137
- UniProt ID
- P10636
- Long Name
- Microtubule Associated Protein Tau
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Secreted
- Post Translation Modifications
- Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases, and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly.
Phosphorylation decreases with age.
PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur.
O-glycosylated. O-GlcNAcylation content is around 8.2%.
Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.
- Protein Refseq
- NP_001116538.2; NP_001116539.1; NP_001190181.1
- Function
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311).
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270).
Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-674 | Chicken Anti-MAPT Recombinant Antibody (clone pT231/pS235_1); scFv Fragment | WB, ELISA, FACS, Block | Chicken scFv |
| PSBL-705 | Mouse Anti-MAPT Recombinant Antibody (clone DC8E8); scFv Fragment | WB, IF, FuncS | Mouse scFv |
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| CAT | Product Name | Application | Type |
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| BRD-0733MZ | Chicken Anti-TAU Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-174 | Recombinant Mouse Anti-Tau5 Antibody | WB, ELISA, Neut, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2164 | Hi-Affi™ Recombinant Rabbit Anti-MAPT Monoclonal Antibody (DS2164AB) | IHC-P | IgG |
| MOR-4513 | Hi-Affi™ Recombinant Rabbit Anti-MAPT Monoclonal Antibody (TH21DS) | WB, IHC-P, FC | IgG |
| MOR-4714 | Hi-Affi™ Recombinant Rabbit Anti-MAPT Monoclonal Antibody (TH228DS) | WB, IF, ICC, IHC-P, FC | IgG |
| MOR-4715 | Hi-Affi™ Recombinant Rabbit Anti-MAPT Monoclonal Antibody (TH229DS) | WB, IF, ICC, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-090CN | Mouse Anti-MAPT Recombinant Antibody (NS-090CN) | WB, ELISA, IHC, IP, SPR, FuncS | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-090CN-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (NS-090CN-F(E)) | WB, ELISA, IHC, IP | Mouse Fab |
| HPAB-AP145-YC-F(E) | Human Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-AP145-YC-F(E)) | ELISA | Human Fab |
| HPAB-N0171-YC-F(E) | Human Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0171-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-N0172-YC-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0172-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-N0173-YC-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0173-YC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ567 | Mouse Anti-MAPT Recombinant Antibody (clone 10E3) | WB, IHC | Mouse IgG |
| VS3-CJ568 | Rabbit Anti-MAPT Recombinant Antibody (VS3-CJ568) | WB, ICC, IF, FC | Rabbit IgG |
| VS3-CJ569 | Rabbit Anti-MAPT (phospho T231) Recombinant Antibody (VS3-CJ569) | WB, IHC, IP | Rabbit IgG |
| VS3-CJ570 | Rabbit Anti-MAPT (phospho S396) Recombinant Antibody (VS3-CJ570) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-FY894 | Recombinant Rabbit Anti-MAPT (phospho Ser202) Antibody (clone R01-5A7) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY182 | AbPlus™ Anti-MAPT Magnetic Beads (VS-0424-XY182) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4255 | Anti-MAPT Immunohistochemistry Kit | IHC | |
| VS-0525-XY4256 | Anti-Mouse MAPT Immunohistochemistry Kit | IHC | |
| VS-0525-XY4257 | Anti-Rat MAPT Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC120 | Recombinant Anti-MAPT (AA 220-224 x AA 506-511) Biparatopic Antibody, Tandem scFv (Clone 13A6 x Clone 19G10) | ELISA | Tandem scFv |
| VS-0525-YC121 | Recombinant Anti-MAPT (AA 506-511 x AA 537-541) Biparatopic Antibody, Tandem scFv (Clone 19G10 x Clone 10H8) | ELISA | Tandem scFv |
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