Recombinant Anti-NOTCH1 Vesicular Antibody, EV Displayed (VS-0425-YC381)
CAT#: VS-0425-YC381
The Recombinant Anti-NOTCH1 Vesicular Antibody, EV Displayed (VS-0425-YC381) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NOTCH1-expressed cells or tissues. The NOTCH1 is a transmembrane receptor that is part of the Notch signaling pathway, influencing cell development with mutations linked to several conditions, including cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NOTCH1
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Notch receptor 1
- Biological Process
- Angiogenesis, Differentiation, Notch signaling pathway, Transcription, Transcription regulation
- Molecular Function
- Activator, Developmental protein, Receptor
- Cellular Localization
- Nucleoplasm
- Introduction
- This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
- Alternative Names
- TAN1
- Gene ID
- 4851
- UniProt ID
- P46531
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Related Diseases
Breast Cancer
Endocrine Resistance
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1747z | Mouse Anti-NOTCH1 Recombinant Antibody (clone 21H9) | WB, ICC, IF, IHC | Mouse IgG2b |
| HPAB-AP750-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133) | ELISA, Block | Human IgG1 |
| HPAB-AP751-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155) | Block | Human IgG1 |
| HPAB-AP752-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49) | ELISA | Human IgG1 |
| HPAB-AP753-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104) | ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H11 | Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab) | Inhib | IgG2 - lambda |
| TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
| TAB-542MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-542MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
| TAB-544MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
| PABX-152-S (P) | Recombinant Human Anti-NRR1 Antibody scFv Fragment | ELISA, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-660 | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment | ELISA | Human scFv |
| HPAB-0078-YC-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51); scFv Fragment | IHC | Mouse scFv |
| NS-060CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| HPAB-0044LY-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody; scFv Fragment (HPAB-0044LY-S(P)) | WB | Mouse scfv |
| HPAB-0681-WJ-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
| TAB-540MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-540MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
| TAB-539MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-539MZ-S(P)) | WB, Competition ELISA | Rat scFv |
| TAB-540MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-540MZ-S(P)) | WB, Competition ELISA | Rat scFv |
| TAB-543MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (mAb N248A) | ELISA, WB, Luciferase reporter assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-545MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23814) | ELISA | Human antibody |
| TAB-546MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23418.8) | ELISA | Human antibody |
| TAB-547MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-547MZ-S(P)) | ELISA | Human scFv |
| TAB-548MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-548MZ-S(P)) | ELISA | Human scFv |
| PABX-152-F (E) | Recombinant Human Anti-NRR1 Antibody Fab Fragment | ELISA, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
| NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
| NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
| NS-063CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
| NS-063CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0044LY-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody; Fab Fragment (HPAB-0044LY-F(E)) | WB | Mouse Fab |
| HPAB-AP750-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP751-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP752-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP753-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H11) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC79 | Rabbit Anti-NOTCH1 Antibody (VS-0924-YC79) - Cancer Stem Cell Marker | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY345 | Mouse Anti-NHP NOTCH1 Recombinant Antibody (clone mN1A) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC828 | CytoStream™ Rabbit Anti-NOTCH1 Recombinant Antibody (VS13-YC828) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| VS13-YC829 | CytoStream™ Rabbit Anti-NOTCH1 Polyclonal Antibody (VS13-YC829) | WB, IHC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY159 | Human Anti-NOTCH1 scFv-Fc Chimera (VS-0425-FY159) | ELISA, Inhib, WB, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1506 | Anti-NOTCH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4907 | Anti-Mouse NOTCH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4906 | Anti-Human NOTCH1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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