Anti-Human NOTCH1 Recombinant Antibody (A12.2) (CAT#: TAB-544MZ)

This antibody shows a neutralization activity and can inhibit Notch ligand-induced signaling with the ability to inhibit growth of HPB-ALL cells.


Specific Inquiry
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FuncS

Figure 1 shows the results of a luciferase reporter assay comparing the antibodies N248A and A12.2.

Figure 1 shows the results of a luciferase reporter assay comparing the antibodies N248A and A12.2.

ELISA

Figure 2 shows the results of domain swap and an ELISA assay to analyze the binding epitopes of A12.2 as compared to N248A.

Figure 2 shows the results of domain swap and an ELISA assay to analyze the binding epitopes of A12.2 as compared to N248A.

Inhib

Figure 3 shows the analysis of the ability of A12.2 to inhibit growth of HPB-ALL cells.

Figure 3 shows the analysis of the ability of A12.2 to inhibit growth of HPB-ALL cells.


Specifications

  • Immunogen
  • Human Notch1
  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • A12.2
  • Applications
  • ELISA, FuncS, Inhib
  • Related Disease
  • T-cell acute lymphoblastic leukemia (T-ALL), breast cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone A12.2"

See other products for "NOTCH1"

Mouse Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1786CQ Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) FC, BL IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H11 Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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