Anti-Human NOTCH1 Recombinant Antibody (23418.8) (CAT#: TAB-546MZ)

This monoclonal antibody binds and inhibits biological activities of human Notch1. It can be potentially used to treat cell proliferative diseases and disorders, including cancers associated with activation or over-expression of Notch1.


Specific Inquiry
  • Size:
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Inhib

Figrue 1 summarizing results from experiments measuring Notchl receptor signaling induced by co-culture with ligand-expressing cells.

Figrue 1 summarizing results from experiments measuring Notchl receptor signaling induced by co-culture with ligand-expressing cells.

FuncS

Figure 2 summarizing results from experiments measuring ligand-induced activation and subsequent intracellular domain (ICD) cleavage of Notchl.

Figure 2 summarizing results from experiments measuring ligand-induced activation and subsequent intracellular domain (ICD) cleavage of Notchl.

FuncS

Figure 3 summarizing results from an experiment to measure thymocyte cell numbers from mice treated with antibodies 23814 and 23814.8.

Figure 3 summarizing results from an experiment to measure thymocyte cell numbers from mice treated with antibodies 23814 and 23814.8.

Inhib

Figure 4 is a graph summarizing results from an experiment to measure inhibition of growth of Notchl/Jagl directed complementation tumors by treatment with 20 mg/kg of antibodies 23814 (■), 23814.8 (A), or hIgG control (·).

Figure 4 is a graph summarizing results from an experiment to measure inhibition of growth of Notchl/Jagl directed complementation tumors by treatment with 20 mg/kg of antibodies 23814 (■), 23814.8 (A), or hIgG control (·).

Inhib

Figure 5 is a graph summarizing results from an experiment to measure inhibition of growth of Calu6 xenograph tumors by treatment with 20 mg/kg of antibody 23814 (A) or hIgG control (■).

Figure 5 is a graph summarizing results from an experiment to measure inhibition of growth of Calu6 xenograph tumors by treatment with 20 mg/kg of antibody 23814 (A) or hIgG control (■).


Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • 23418.8
  • Applications
  • FuncS, Inhib
  • Related Disease
  • Cancers associated with activation or over-expression of Notch1

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Inhibition.

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 23418.8"

See other products for "NOTCH1"

Humanized Antibody

Mouse Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1786CQ Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) FC, BL IgG1, κ

Rabbit Monoclonal Antibody

Neuroscience Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H11 Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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