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    Anti-Human NOTCH1 Recombinant Antibody (23418.8) (CAT#: TAB-546MZ)

    This monoclonal antibody binds and inhibits biological activities of human Notch1. It can be potentially used to treat cell proliferative diseases and disorders, including cancers associated with activation or over-expression of Notch1.

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Inhib

    Figrue 1 summarizing results from experiments measuring Notchl receptor signaling induced by co-culture with ligand-expressing cells.

    Figrue 1 summarizing results from experiments measuring Notchl receptor signaling induced by co-culture with ligand-expressing cells.

    FuncS

    Figure 2 summarizing results from experiments measuring ligand-induced activation and subsequent intracellular domain (ICD) cleavage of Notchl.

    Figure 2 summarizing results from experiments measuring ligand-induced activation and subsequent intracellular domain (ICD) cleavage of Notchl.

    FuncS

    Figure 3 summarizing results from an experiment to measure thymocyte cell numbers from mice treated with antibodies 23814 and 23814.8.

    Figure 3 summarizing results from an experiment to measure thymocyte cell numbers from mice treated with antibodies 23814 and 23814.8.

    Inhib

    Figure 4 is a graph summarizing results from an experiment to measure inhibition of growth of Notchl/Jagl directed complementation tumors by treatment with 20 mg/kg of antibodies 23814 (■), 23814.8 (A), or hIgG control (·).

    Figure 4 is a graph summarizing results from an experiment to measure inhibition of growth of Notchl/Jagl directed complementation tumors by treatment with 20 mg/kg of antibodies 23814 (■), 23814.8 (A), or hIgG control (·).

    Inhib

    Figure 5 is a graph summarizing results from an experiment to measure inhibition of growth of Calu6 xenograph tumors by treatment with 20 mg/kg of antibody 23814 (A) or hIgG control (■).

    Figure 5 is a graph summarizing results from an experiment to measure inhibition of growth of Calu6 xenograph tumors by treatment with 20 mg/kg of antibody 23814 (A) or hIgG control (■).


    Specifications

    • Host Species
    • Human
    • Derivation
    • Phage display library
    • Type
    • Human antibody
    • Specificity
    • Human
    • Clone
    • 23418.8
    • Applications
    • FuncS, Inhib
    • Related Disease
    • Cancers associated with activation or over-expression of Notch1

    Applications

    • Application Notes
    • This antibody has been reported for use in Functional Assay, Inhibition.

    Target

    • Alternative Names
    • NOTCH1; AOS5; AOVD1; TAN1; hN1

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 23418.8"

    See other products for "NOTCH1"

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    Humanized Antibody Products Fab Antibody Products Mouse Antibody Products Human Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products IgG Antibody Products ScFv Antibody Products Neuroscience Antibody Products ADCC Enhanced Antibody Products Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research ScFv-Fc Chimera Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    TAB-H11 Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab) Inhib IgG2 - lambda
    TAB-541MZ Human Anti-NOTCH1 Recombinant Antibody (TAB-541MZ) Neut, WB Humanized antibody
    TAB-542MZ Human Anti-NOTCH1 Recombinant Antibody (TAB-542MZ) Neut, WB Humanized antibody
    TAB-544MZ Anti-Human NOTCH1 Recombinant Antibody (A12.2) ELISA, FuncS, Inhib Humanized antibody
    PABX-152-S (P) Recombinant Human Anti-NRR1 Antibody scFv Fragment ELISA, Neut, FuncS scFv

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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